The American Cancer Society anticipates that during 1995, 244000 new cases of cancer of the prostate will have been diagnosed in the United States, with 40400 deaths from the disease process. The rapid increase in the actual number of new cases in the United States is directly related to more regularized digital rectal examinations and the more frequent and widespread use of prostate-specific antigen (PSA) screening programs. As a conse quence, major controversies have emerged in how best to manage the patient with cancer of the prostate. These include the necessity of PSA screening programs, how to interpret PSA values, what imaging studies are most appropriate for definition of the true extent of the disease process, the value of pretreatment surgical staging of the disease process, and the value of different treatments. The latter encompass a wide range of options: observa tion, radical prostatectomy, the Walsh-type prostatectomy procedure, definitive external beam radiation therapy, local interstitial implantation using iodine-125, iridium-l92, or palladium-103, orchiectomy, cryosurgery, hyperthermia, and various antitestosterone agents such as estrogens or LH,RH agonists. The present volume deals with the major parameters of controversy with regard to cancer of the prostate and will enable the reader to acquire a better understanding of the disease and how best it might be managed to achieve an optimal outcome with a minimum of complications.
The book provides comprehensive coverage of innovations in the management of capsula-confined and metastatic endocrine-responsive and endocrine-unresponsive prostate cancer. Besides detailed chapters on the entire range of treatment options, there are background chapters on the epidemiology, development, and natural history of the untreated disease. The controversial issue of the value of prostate-specific antigen as a screening tool is also fully discussed. All chapters have been written by internationally recognized experts in their fields. This volume is an authoritative review of treatment concepts that will appeal to all concerned with the diagnosis and treatment of carcinoma of the prostate.
1 The Epidemiology and Etiology of Prostate Cancer.- 2 Natural History of Prostate Cancer.- 3 Screening for Prostate Cancer.- 4 Pathology of Prostatic Carcinoma.- 5 Chromosome Abnormalities in Adenocarcinoma of the Prostate.- 6 Radioimmunoscintigraphy and Radioimmunotherapy in Cancer of the Prostate.- 7 Imaging Modalities in Diagnosis and Staging of Carcinoma of the Prostate.- 8 Conservative Management of Carcinoma of the Prostate.- 9 Surgical Treatment of Carcinoma of the Prostate.- 10 Patterns of Failure in Surgically Treated Patients.- 11 Complications of Radical Prostatectomy.- 12 Radical Retropubic Prostatectomy: The USC Experience.- 13 Surgical Salvage Options in Patients with Recurrent Tumor Following Radiotherapy.- 14 The Role of Prostate-Specific Antigen in the Management of Prostate Cancer.- 15 Treatment Results with External Beam Radiation Therapy for Localized Carcinoma of the Prostate (Stages T1B, T2, and T3).- 16 Localized Carcinoma of the Prostate: Patterns of Failure with External Beam Radiation Therapy.- 17 External Beam Radiotherapy for Localized Prostatic Cancer at Stanford: Update at the 38th Year.- 18 Use of Brachytherapy Techniques in the Management of Carcinoma of the Prostate.- 19 Treatment-Related Complications in Patients with Carcinoma of the Prostate: A Review.- 20 Adjuvant Radiotherapy Following Radical Prostatectomy in the Management of Carcinoma of the Prostate.- 21 Conformal Radiotherapy for Carcinoma of the Prostate.- 22 Systemic Therapy for Carcinoma of the Prostate.- 23 Hyperthermia for Carcinoma of the Prostate.- 24 Cryotherapy for Carcinoma of the Prostate.- List of Contributors.