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Bone Marrow Failure
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Main description:

This book presents the latest scientific knowledge on inherited and acquired bone marrow failure syndromes, describing the advances in understanding of genetics and pathophysiology that have been achieved as a result of high-throughput DNA sequencing, RNA expression studies, and modern biochemistry techniques. The full range of relevant conditions is covered, including acquired aplastic anemia, Fanconi anemia, ribosomopathies, telomeropathies, dyskeratosis congenita, Shwachman-Diamond syndrome, Diamond-Blackfan anemia, and congenital neutropenias and thrombocytopenias. In addition, it is explained how the study of these rare diseases has uncovered important new science and elucidated the pathophysiology of more common hematological and oncological diseases. A treatment-specific chapter describes options ranging from the conventional to the cutting edge. Bone Marrow Failure will be of value for both trainee and practicing hematologists and oncologists.


Contents:

1. The Cellular and Molecular Mechanisms of Hematopoiesis2. Acquired Aplastic Anemia 3. Pediatric Myelodysplastic Syndromes4. Fanconi Anemia: A Pathway of Hematopoeisis and Cancer Predisposition5. Ribosomopathies Through a Diamond Lens6. Dyskeratosis Congenita and the Telomere Biology Disorders7. Diamond Blackfan Anemia8. Shwachman-Diamond Syndrome9. Hematopoietic Cell Transplantation for the Treatment of Patients with Bone Marrow Failure Syndromes10. Inherited Neutropenias and Their Insights into Cellular and Developmental Biology11. Inherited Thrombocytopenias


PRODUCT DETAILS

ISBN-13: 9783319614205
Publisher: Springer (Springer International Publishing AG)
Publication date: October, 2018
Pages: None
Weight: 818g
Availability: Available
Subcategories: Haematology, Oncology, Paediatrics and Neonatal

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