Main description:

Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development.

Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder.

Contents:

1. Biomarkers in Bipolar Disorder: Overview
2. RNA and Micro-RNA Biomarkers in Bipolar Disorder
3. Metabolomics in Bipolar Disorder
4. Behavioral Models of Bipolar Disorder
5. Structural Neuroimaging in Bipolar Disorder
6. Neurochemical Imaging Findings in Bipolar Disorder
7. Pharmacogenomics and Precision Psychiatry in Bipolar Disorder
8. Translating Biomarkers from Bench to Bedside in Bipolar Disorder
9. Genetic (GWAS) Biomarkers in Bipolar Disorders
10. Mitochondrial Dysfunction in Bipolar Disorder
11. Aging Mechanisms in Bipolar Disorder
12. Staging and Neuroprogression in Bipolar Disorders
13. Neuro-immune Pathways in Bipolar Disorder
14. Glutamatergic Dysfunction in Bipolar Disorder
15. Neurocognitive Endophenotypes and Biomarkers in Bipolar Disorder
16. DNA Methylation in Bipolar Disorder
17. Biomarkers of Lithium Efficacy in Bipolar Disorders
18. Neuroendocrine Pathways in Bipolar Disorders
19. Intracellular Signaling in Bipolar Disorder
20. Circadian Rhythms and Bipolar Disorder
21. DNA Damage and Repair Mechanisms in Bipolar Disorder
22. Microbiome and Bipolar Disorder
23. Bipolar Disorder and Plasticity: A Key Target for New Treatments
24. Proteomic Approaches for Biomarker Discovery in Bipolar Disorder
25. Drug Development in Bipolar Disorders: New Therapeutic Targets