Main description:

As sites of action for drugs used to treat schizophrenia and Parkinson's disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette's syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.

Contents:

Table of Contents Preface Historical Overview: Introduction to the Dopamine Receptors
Philip Seeman
Gene and Promoter Structures of the Dopamine Receptors
Ursula M. D'Souza
Structural Basis of Dopamine Receptor Activation
Irina S. Moreira, Lei Shi, Zachary Freyberg, Spencer S. Eriksen, Harel Weinstein, and Johnathan A. Javitch
Dopamine Receptor Subtype-Selective Drugs: D1-like Receptors
David E. Nichols
Dopamine Receptor Subtype-Selective Drugs: D2-like Receptors
Olaf Prante, Miriam Doerfler, and Peter Gmeiner
Dopamine Receptor Signaling: Intracellular Pathways to Behavior
Robert J. Romanelli, John T. Williams, and Kim A. Neve
Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons
Weixing Shen and D. James Surmeier
Regulation of Dopamine Receptor Trafficking and Responsiveness
Melissa L. Perreault, Vaneeta Verma, Brian F. O'Dowd and Susan R. George
Dopamine Receptor-Interacting Proteins
Lisa A. Hazelwood, R. Benjamin Free, and David R. Sibley
Dopamine Receptor Oligomerization
Kjell Fuxe, Daniel Marcellino, Diego Guidolin, Amina Woods and Luigi Agnati
Dopamine Receptor Modulation of Glutamatergic Neurotransmission
Carlos Cepeda, Veronique M. Andre, Emily L. Jocoy and Michael S. Levine
Unraveling the Role of Dopamine Receptors in vivo: Lessons from Knockout Mice
Emanuele Tirotta, Claudia De Mei, Chisato Iitaka, Maria Ramos, Dawn Holmes, and Emiliana Borrelli
Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models
Gerard J. O'Sullivan, Colm O'Tuathaigh, Katsunori Tomiyama, Noriaki Koshikawa, and John L. Waddington
Dopamine Modulation of the Prefrontal Cortex and Cognitive Function
Jeremy K. Seamans and Trevor W. Robbins
In VivoImaging of Dopamine Receptors
Anissa Abi-Dargham and Marc Laruelle
Dopamine Receptors and the Treatment of Schizophrenia
Nathalie Ginovart and Shitij Kapur
Dopamine Receptor Subtypes in Reward and Relapse
David W. Self
Dopamine Receptors and the Treatment of Parkinson's Disease
Eugenia V. Gurevich and Vsevolod V. Gurevich
Dopamine Receptor Genetics in Neuropsychiatric Disorders
Frankie H. F. Lee and Albert H. C. Wong