Main description:

G-protein coupled receptors (GPCRs) constitute a large superfamily of proteins that have been historically well represented as drug targets. As such, many of the volumes within The Receptors series have focused their attention on rec- tor subfamilies in the GPCR superfamily (e. g. , adrenergic, serotonergic, do- minergic). While chemokine receptors are relatively young, in terms of the knowledge that has accumulated regarding their roles in physiology and pat- logy, it is clear that this GPCR subfamily is dwar? ng all others with respect to the total number of receptors and their functional diversity. The breadth of the chemokine ? eld was not fully appreciated in the early days of chemokine d- covery, when the characterization of these molecules was largely a curiosity of a small set of biologists primarily interested in in? ammation. Presently, the ? eld of chemokinology is quite diverse, and it is nearly impossible to stay informed on all aspects of chemokine biology. Nonetheless, this book seeks to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors into a single volume, providing an excellent resource for those entering the ? eld or the most experienced c- mokinologist seeking new insights. In the chapters, leading authorities consider structural and cellular aspects of chemokines and chemokine receptors, and more notably, discuss the roles of these molecules in a variety of disease states that transcend their classically de? ned role(s) in in? ammation.

Feature:

Contains cutting-edge information ranging from basic molecular and cellular mechanisms to physiological and pathological roles of chemokines

Focuses on several areas, including the birth, maturation, and structure of Chemokines; Neutrophil, Dendritic, and Lymphocyte trafficking; and Chemokine Receptors in diseases such as AIDs and lung cancer

Back cover:

To date, there are over twenty different chemokine receptors, binding nearly fifty unique ligands that have been identified. In Chemokine Receptors, leading investigators attempt to distill the large body of literature ranging from basic molecular and cellular mechanism of chemokine receptors, to physiological and pathological roles of chemokines. Chemokines exhibit a tremendous functional diversity and participate in a wide variety of processes that include inflammation, innate and adaptive immunity, immune cell differentiation, angiogenesis, tumorigenesis, development, neurobiology and viral pathogenesis. Chemokine Receptors targets the pharmaceutical industry, provides an authoritative perspective on the future direction of this field, and insights into areas of active development of novel therapeutics.

Contents:

The Chemokine Receptors, Editors: Jeffrey K. Harrison and Nicholas W.
Lukacs

Table of Contents

Chapter

1. The Birth and Maturation of Chemokines and Their Receptors
*Nicholas W. Lukacs, Ph.D. and *Jeffrey K. Harrison, Ph.D.
University of Michigan and University of Florida

2. The Structural Biology of Chemokines
*Elias Lolis, Ph.D. and James Murphy, Ph.D.
Yale University

3. Chemokine Receptors: A Structural Overview
*Gerard J. Graham, Ph.D. and Robert J. Nibbs, Ph.D.
University of Glasgow

4. Chemokine Signalling in T Lymphocytes Migration: the Role of
Phosphoinositide 3-kinase
Laura Smith, Adam Webb, and *Stephen G. Ward, Ph.D.
University of Bath

5. Chemokine Receptors and Neutrophil Trafficking
*Teizo Yoshimura, M.D., Ph.D.
National Cancer Institute at Frederick

6. Chemokine Receptors and Dendritic Cell Trafficking
*Hiroyuki Yoneyama, M.D., Ph.D., Kenjiro Matsuno, M.D., Ph.D., and
Kouji Matsushima, M.D., Ph.D.
University of Tokyo

7. Chemokine Receptors and Lymphocyte Trafficking
Michael N. Hedrick, Ph.D. and *Joshua M. Farber, M.D.
National Institute of Allergy and Infectious Disease/National
Institutes of Health

8. Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells
and Hematopoiesis
*Chang Kim, Ph.D.
Purdue University

9. Chemokines in Transplantation Biology
*Peter Jon Nelson, Ph.D., Stephan Segerer, M.D., and Detlef
Schlondorff, M.D.
University of Munich

10. The Chemokine System and Arthritis
Marlon P. Quinones, M.D., Fabio Jimenez, Carlos A. Estrada, M.D.,
Herman Martiniez, M.D., and *Seema Ahuja, M.D.
University of Texas-San Antonio

11. Chemokine Receptors in Atherosclerosis
Maya R. Jerath, Mildred Kwan, Peng Liu, and *Dhavalkumar D. Patel,
M.D., Ph.D.
University of North Carolina

12. Chemokine Receptors in Allergic Lung Disease
Dennis M. Lindell, Ph.D.and *Nicholas W. Lukacs, Ph.D.
University of Michigan

13. Chemokine Receptors and HIV/AIDS
*Tzanko S. Stanchev, M.D. and *Christopher C. Broder, Ph.D.
Uniformed Services University of Health Sciences

14. Chemokines and Their Receptors in Fibrosis
Glenda Trujillo, Ph.D. and *Cory M. Hogaboam, Ph.D.
University of Michigan

15. Chemokines and Angiogenesis
*Michael P. Keane, M.D., John A. Belperio, M.D., and Robert M.
Strieter, M.D.
University of California, Los Angeles and University of Virginia

16. Chemokine Receptors in Cancer: Pathobiology and Potential
Therapeutic Targets
Tonya C. Walser, Ph.D. and *Amy M. Fulton, Ph.D.
University of Maryland

17. Chemokine Receptors in Neuroinflammation
Astrid E. Cardona, Ph.D. and *Richard M. Ransohoff, M.D.
Lerner Research Institute, Cleveland Clinic

18. Pharmaceutical Targeting of Chemokine Receptors
*Sofia Rubiero, Ph.D. and Richard Horuk, Ph.D.
Berlex Biosciences

* indicates corresponding authors