Main description:

This volume contains the proceedings of a symposium held in Marseille on April 6, 1992, on the topic "Heterogeneity of Alzheimer's disease. " This was the eighth of a continuing and very successful series of meetings related to Alzheimer's disease organized by the Fondation Ipsen pour la Recherche Therapeutique. These symposia, known as "Colloques medecine et recherche," started in 1987 and have dealt with widely different aspects of the disease such as immunology, genetics, neuronal grafting, biological markers, imaging, growth factors, and last year's less conventional topic of Neurophilo- sophy and Alzheimer's disease. The next IPSEN symposium dedicatet to Alz- heimer's disease will take place in Lyon on June 21, 1993, and will deal with "Amyloid protein precursors in development, aging, and alzheimer's disease. " It is being organized by Konrad Beyreuther, Colin Masters, Marc Trillet, and Yves Christen. Until a few years ago, several names were used to refer to the most common cause of dementia in the elderly. They included such terms as "senile psycho- sis," "organic brain syndrome," and "senile dementia.
" Following Kraepelin, the term "Alzheimer's disease" was often restricted to an uncommon condition starting at a younger age (before 60 or 65 years of age).

Contents:

An Overview of Scientific Issues Associated with the Heterogeneity of Alzheimer's Disease.- A Comparison of Clinical Outcome and Survival in Various Forms of Alzheimer's Disease.- Prognostic Implications of Symptomatic Behaviors in Alzheimer's Disease.- Heterogeneous Disappearance of Knowledge in Alzheimer's Disease.- Neuropsychological Aspects of Alzheimer's Disease: Evidence for Inter- and Intra-Function Heterogeneity.- Primary Progressive Aphasia: Sharpening the Focus on a Clinical Syndrome.- Therapeutic Drug Trials and Heterogeneity of Alzheimer's Disease.- Pro and Con for Heterogeneity of Alzheimer's Disease: A View from an Epidemiologist.- Heterogeneity in Familial Alzheimer's Disease.- Molecular Genetic Evidence for Etiologic Heterogeneity of Alzheimer's Disease.- Alzheimer's Disease: many Aetiologies; one Pathogenesis.- Locus Heterogeneity of Alzheimer's Disease.- Familial Alzheimer's Disease in Germans from Russia: A Model of Genetic Heterogeneity in Alzheimer's Disease.- Protein Phosphorylation Regulates Processing of the Alzheimer ?/A4-Amyloid Precursor Protein.- Alzheimer's Disease and Neuroanatomy: Hypotheses and Proposals.- Distribution of Tau-PHF in Brodmann Areas Reveals a Heterogeneity of the Degenerating Process in Rostro-Caudal Regions and as a Function of Age.- Alzheimer's Disease and Age-Related Pathology in Diffuse Lewy Body Disease.