Published February, 2015
By Yves Christen and Mathias Jucker
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
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Availability: Available

This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimers disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration.

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Published January, 2015
By Yves Christen, Richard I. Morimoto and Vice-President Yves Christen
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
Rating:
Availability: Available

Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

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Published April, 2014
By Jean-Francois Demonet and Bradley T. Hyman
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
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Availability: Available

From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas.

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Published May, 2013
By Yves Christen and Thomas Curran
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
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Availability: Available

However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

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Published April, 2013
By Yves Christen and Mathias Jucker
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
Rating:
Availability: Available

This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimers disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration.

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Published December, 2012
By Yves Christen and Richard I. Morimoto
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
Rating:
Availability: Available

Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

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Published October, 2012
By Y. Christen, A. Israel, B. de Strooper, F. Checler and Alain Israel
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
Rating:
Availability: Available

Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders?

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Published August, 2012
By K. Beyreuther, C.L. Masters and Marc Trillet
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
Rating:
Availability: Available

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Published May, 2012
By Patricia S. Churchland and Patricia Churchland
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
Rating:
Availability: Available

Any mention of the relationship, still poorly understood, between body (or brain) and mind invariably invokes the name of Descartes, who is often thought of as the father of modern philosophy and perhaps of neurophilosophy.

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Published May, 2012
By Suzanne Craft
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Research and Perspectives in Alzheimer's Disease
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Availability: Available

This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.

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