Main description:

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicologic testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the hemopoietic system, is the eighth volume of a set prepared under the sponsorship of the International Life Sciences In stitute (ILSI).

Contents:

Bone Marrow and Peripheral Blood.- Structure and function.- Regulation of Hemopoiesis.- Evaluation of Blood and Bone Marrow, Rat.- Normal Blood Cell Values, Rat.- Neoplasms.- Granulocytic Leukemia, Rat.- Granulocytic Leukemia, Mouse.- Megakaryocytic Leukemia, Mouse.- Histiocytic Sarcoma, Rat.- Histiocytic Sarcoma, Mouse.- Nonneoplastic Lesions.- Myelofibrosis, Mouse.- Chediak-Higashi Syndrome, Mouse.- Assessment of Toxicologic Effects upon Bone Marrow and Related Tissues.- Parasites.- Hemobartonellosis and Eperythrozoonosis.- Trypanosoma Brucei Infection, Mouse.- Lymph Nodes.- Structure and function.- Identification and Functional Characteristics of Lymphocytes with Natural Killer Activity.- Identification and Functional Characteristics of T Lymphocytes.- B-Cell Function and Ontogeny.- Identification and Functional Characteristics of Monocytes/Macrophages.- Immunohistochemistry, Lymphoid Cells, Mouse.- Sources of Antibodies and Immunological Reagents Used for Immunohistochemistry.- Normal Anatomy, Histology, Immunohistology, and Ultrastructure, Lymph Node, Rat.- Neoplasms.- Classification of Mouse Lymphoid Cell Neoplasms.- Immunoblastic Lymphoma, Ileocecal Lymph Nodes, LOU/C Rat.- Follicular Center Cell Lymphoma, Mouse.- A Morphologic Classification of Hemopoietic Tumors, Rats.- Nonneoplastic Lesions.- Classification of Reactive Lesions of Lymph Nodes.- Autoimmune Hemolytic Anemia, NZB Mice.- Toxic Effects on the Immune System, Rat.- Spleen.- Structure and Function.- Normal Anatomy, Histology, Ultrastructure, Rat.- Neoplasms.- Large Granular Lymphocyte Leukemia, Rat.- Immunohistochemistry of Large Granular Lymphocyte Leukemia, Rat.- Mast Cell Neoplasms, Mouse.- Erythroleukemia, Mouse.- Early Follicular Center Cell Lymphoma, Mouse.- Fibrosarcoma, Spleen, Rat.- Nonneoplastic Lesions.- Classification of Reactive Lesions, Spleen.- Pigment Deposition, Rat, Mouse.- Extramedullar Hemopoiesis, Spleen, Rat.- Amyloidosis, Spleen, Mouse.- Fibrosis, Spleen, Rat.- Thymus.- Structure and Function.- Normal Anatomy, Histology, Immunohistology, Ultrastructure, Rat.- Development and Aging, Thymus, Rat.- Neoplasms.- Lymphoblastic Lymphomas, Mouse.- Thymoma, Lymphocytic, Rat.- Thymoma, Epithelial, Rat.- T-Cell Lymphoma, Thymic Origin, Rat.- Nonneoplastic Lesions.- Atrophy of Thymus Induced by Cytostatic Chemicals, Rat.- Other Hemopoietic Tissues.- Bronchus-Associated Lymphoid Tissue, Rat, Normal Structure.- Gut-Associated Lymphoid Tissue, Rodent, Normal Structure and Function.- Intraepithelial Leukocytes, Murine.