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Handbook of Genomics and the Family
Psychosocial Context for Children and Adolescents
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Today, individuals have greater access to information about their healththaneverbefore(Randeree,2009;Eysenbach,2008).Muchofthis changeisdue,inlargepart,toadvancesinbiotechnologyandtheseque- ing of the human genome (Manolio & Collins, 2009). It is now possible, forexample,forindividualstologontotheInternetand,forafeeofs- eral hundred dollars, order an at-home DNA collection kit and have the resultsofamyriadofgenetictestsdelivereddirectlytotheire-mailinbox (Gurwitz&Bregman-Eschet,2009).Insomecases,thesetestresultsmay indicatepersonalriskforcommonchronicdiseases,suchascertainforms ofcancer,diabetes,cardiovasculardisease,andseveralothers.Companies marketing these test kits often claim that promoting greater access to and awareness of the association between genes and health, and one's genetic susceptibilities to disease, leads to more proactive and insig- fulmethodsofindividualhealthmanagement(Hogarth,Javitt,&Melzer, 2008). Moreover, it is consistent with an emerging trend in medicine - that of consumer-oriented medicine - which places health information toolsdirectlyinthehandsofpatientsunderthepremiseoffosteringbetter patient-providercollaboration(Silvestre,Sue,&Allen,2009).
Though the principles behind this direct-to-consumer approach to genetics seem laudable and perhaps even exciting, there is consid- ablecontroversyastowhat,ifany,utilitytheinformationactuallyholds (Geransar Wasson,Cook,&Helzlsouer,2006).Unlike geneticteststhatarediagnostic(e.g.,chromosomeanalysisforDowns- drome)orhighlypredictive(e.g.,BRCA1andBRCA2testingforhereditary breast-ovarian cancer risk), this new wave of presymptomatic predictive genetictestsforcommondiseaseyieldsresultsthataremuchmoreunc- tainbecausethestatisticalmodelsonwhichtheyarepresentlybasedare imperfectandwithlimiteddata(Ng,Murray,Levy,&Venter,2009). Theabovescenarioraisesmanyquestionsfortoday'shealth-carec- sumers. For example, for whom is this information applicable, and for whatpopulationsorsubpopulationsisitnot?Underwhatcircumstances might this information be useful, and when should it be disregarded as irrelevant?Andperhapsmostimportantly,what,ifanything,canbedone inlightofinformationaboutpersonalgeneticrisktoeffectivelylowerthe oddsofbecomingsickandraisetheoddsofstayinghealthy? vii viii PREFACE Becausetheprevalenceofmostdiseasesvariesasafunctionofage, gender, race/ethnicity, and other personal characteristics, answers to these questions are complex and many are just beginning to be und- stood(Khouryetal.
,2009).Someexpertshaveconcludedthattheanswers tosuchquestionsremainoutofreachatthepresenttimeandmayc- tinue to be elusive for another 5-10 years (Frazer, Murray, Schork, & Topol,2009).Yet,twenty-?rstcenturyhealth-careconsumers,providers, and policy makers face these choices now about incorporating personal genetic information into health management and often do so without a complete and accurate understanding of the potential impact of their decisionsonmultiplelevels(Carlson,2009).


Contents:

The New Era of Genomics: Childhood and Society Revisited.- Key Concepts in Human Genomics and Molecular Biology.- Key Concepts in Human Genomics and Psychology.- Understanding Childhood Gene, Environment, and Gene x Environment Interaction Effects.- Goals, Process, and Content of Genetic Counseling: Applications to Children, Adolescents, and Their Families.- Genomics and the Family: Integrative Frameworks.- Potential Impact of Genomic Information on Parent-Child Relationships.- Potential Impact of Genomic Information on Childhood Sibling Relationships.- Family Communication of Genomic Information.- Developmental Perspectives on Health and Risk Communication: Theories and Applied Methodologies for Genomics.- Prenatal Diagnosis and Carrier Screening.- Single Gene Disorders: Cystic Fibrosis, Sickle Cell Disease, Duchenne's Muscular Dystrophy and Others.- Cancer.- Diabetes.- Cardiovascular Disease.- Obesity.- Tobacco, Alcohol, and Other Risk Behaviors .- Childhood Psychiatric and Neurodevelopmental Genomics.- Bioethical Perspectives on Pediatric Gene Therapy and Pharmacogenomics.- Informed Consent and the Protection of Human Subjects in Genomic Research with Children, Adolescents, and Families .- Ethical, Legal, and Social Issues in the Genetic Testing of Minors.- National Policy Perspectives on Pediatric Genetic Testing.- Privacy and Insurance Issues in Pediatric Genetic Testing.- Training, Practice, and Collaboration: New Opportunities for Pediatric Psychology and Genomic Medicine.-Prevention and Control: Genes, Behavior, and Beyond.


PRODUCT DETAILS

ISBN-13: 9781461423959
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: December, 2011
Pages: 644
Weight: 1208g
Availability: Available
Subcategories: General Practice, Genetics, Paediatrics and Neonatal, Psychiatry, Psychotherapy
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