Established since 1942 as the leading hematology textbook, Wintrobe's Clinical Hematology is now in its thoroughly revised Twelfth Edition. The text continues its tradition of correlating basic science with the clinical practice of hematology and is organized to help physicians find clinical answers quickly and easily.

The Twelfth Edition is in full color for the first time, includes more international contributors, and has two new editors, Daniel A. Arber, MD and Robert T. Means, Jr., MD. Highlights include expanded coverage of molecular genetics and pathogenesis, more hematopathology illustrations, and current information on new medications and their rapid bench-to-bedside development. Four new chapters cover anemias unique to the newborn period, pathology of LHC and other histiocytic disorders, tumors of the spleen, and pathology and classification of myeloproliferative disorders and mast cell disease.

A companion Website will offer the fully searchable text and an image bank.

VOLUME 1

PART I Laboratory Hematology

• CH 1. Examination of the Blood and Bone Marrow
• CH 2. Clinical Flow Cytometry
• CH 3. Cytogenetics
• CH 4. Molecular Biology and Hematology

PART II The Normal Hematologic System

Section 1. Hematopoiesis

• CH 5. Origin and Development of Blood Cells

Section 2. The Erythrocyte

• CH 6. Erythropoiesis
• CH 7. The Mature Erythrocyte
• CH 8. Destruction of Erythrocytes

Section 3. Granulocytes and Monocytes

• CH 9. Neutrophilic Leukocytes
• CH 10. The Human Eosinophil
• CH 11. Basophilic Leukocytes: Mast Cells and Basophils
• CH 12. Mononuclear Phagocytes
• CH 13. Phagocytosis

Section 4. The Lymphocytes

• CH 14. Lymphocytes and Lymphatic Organs
• CH 15. B Lymphocytes
• CH 16. T Lymphocytes and Natural Killer Cells
• CH 17. Effector Mechanisms in Immunity

Section 5. Hemostasis

• CH 18. Megakaryocytes
• CH 19. Platelet Structure and Function in Hemostasis and Thrombosis
• CH 20. Blood Coagulation and Fibrinolysis
• CH 21. Endothelium: Angiogenesis and the Regulation of Hemostasis

PART III Therapeutic Modalities

• CH 22. Red Cell, Platelet, and White Cell Antigens
• CH 23. Transfusion Medicine
• CH 24. Hematopoietic Stem Cell Transplantation
• CH 25. Gene Therapy for Hematologic Disorders

PART IV Disorders of Red Cells

Section 1. Introduction

• CH 26. Anemia: General Considerations

Section 2. Disorders of Iron Metabolism and Heme Synthesis

• CH 27. Iron Deficiency and Related Disorders
• CH 28. Sideroblastic Anemias
• CH 29. Hemochromatosis
• CH 30. Porphyria

Section 3. Hemolytic Anemia

• CH 31. Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated with Abnormalities of the Erythrocyte Membrane
• CH 32. Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders
• CH 33. Autoimmune Hemolytic Anemia
• CH 34. Alloimmune Hemolytic Disease of the Fetus and Newborn
• CH 35. Paroxysmal Nocturnal Hemoglobinuria
• CH 36. Acquired Nonimmune Hemolytic Disorders

Section 4. Hereditary Disorders of Hemoglobin Structure and Synthesis

• CH 37. Sickle Cell Anemia and Other Sickling Syndromes
• CH 38. Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis
• CH 39. Hemoglobins with Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias

Section 5. Other Red Cells Disorders

• CH 40. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis
• CH 41. Inherited Aplastic Anemia Syndromes
• CH 42. Acquired Aplastic Anemia
• CH 43. Red Cell Aplasia
• CH 44. Congenital Dyserythropoietic Anemias
• CH 45. Anemias Secondary to Chronic Disease and Systemic Disorders
• CH 46. Anemias During Pregnancy and the Postpartum Period
• CH 47. Anemias Unique to the Newborn Period
• CH 48. Erythrocytosis

V O L U M E 2

PART V Disorders of Hemostasis and Coagulation

Section 1. Introduction

Section 2. Thrombocytopenia

Section 3. Other Disorders of Primary Hemostasis

Section 4. Coagulation Disorders Platelet Destruction

Section 5 Thrombosis

PART VI Nonmalignant Disorders of Leukocytes,the Spleen, and/or Immunoglobins

PART VII Hematologic Malignancies

Section 1. General Aspects

Section 2. The Acute Leukemias

Section 4. Lymphoproliferative Disorders

Section 5. Plasma Cell Dyscrasias

Appendices

INDEX