Main description:

White matter injury can result from both ischemic and hemorrhagic stroke as well as a host of other CNS diseases and conditions such as neonatal injuries, neurodegenerative disorders including Alzheimer's disease, traumatic brain injuries, carbon monoxide poisoning, and drug or alcohol overdoses. The extent of white matter injury is extremely important to patient outcomes. Several recent technological developments including advanced neuroimaging and the breeding of new rodent models of white matter injury have provided growing insight into initial damage and repair after a stroke or other damaging event. The proposed book will be the first to provide a systematic expert summary of normal white matter morphology as well as white matter injury following stroke and other CNS injuries.

Contents:

Section I: White Matter and Evaluation

1 White matter: Basic principles of axonal organization and function

Alexander A Velumian and Marina Samoilova

2 Electrophysiology evaluation of white matter injury

Mingke Song, Anna Woodbury, Shanping Yu

3 CADASIL and animal models

Francesco Blasi, PharmD, PhD, Anand Viswanathan, MD, PhD Cenk Ayata, MD

4 Neuroimaging of White Matter Injury: A Multimodal Approach to Vascular Disease

Gary A. Rosenberg, Branko Huisa, Fakhreya Y. Jalal, Yi Yang

5 Diffusion MRI Biomarkers of White Matter Damage in Traumatic Brain Injury

Maria Ly, Samuel Ji, Michael A. Yassa

Section II: White Matter Injury in Stroke and other CNS Disorders

6 Mechanisms underlying the selective vulnerability of developing white matter

Paul A. Rosenberg

7 Neonatal experimental white matter injury

Zhengwei Cai

8 Focal ischemic white matter injury in experimental models

Robert Fern

9 Global ischemic white matter injury in patients

Shinichi Nakao, Yan Xu

10 Experimental global ischemia and white matter injury

Ji Hae Seo, Kazuhide Hayakawa, Nobukazu Miyamoto, Takakuni Maki, Loc-Duyen, Eng H. Lo, Ken Arai

11 White Matter Injury after Experimental Intracerebral Hemorrhage

Kenneth R. Wagner

12 White Matter Repair after Ischemic Injury

Elif G S zmen, S. Thomas Carmichael

13 White Matter Injury in Subarachnoid Hemorrhage in Humans

Gian Marco De Marchis, MD and Stephan A. Mayer, MD

14 Neurodegenerative diseases and white matter injury in patients

George Bartzokis, M.D., Po H. Lu, Psy.D

15 Unmyelinated and myelinated axons exhibit differential injury and treatment response following traumatic brain injury

Thomas M. Reeves, Adele E. Doperalski, Linda L. Phillips

16 Age-Dependent Mechanisms Of White Matter Injury After Stroke

Selva Baltan

17 White matter damage in multiple sclerosis

Maria Victoria Sanchez-Gomez, Fernando Perez-Cerda, Carlos Matute

Section III: Pathophysiology of White Matter Injury

18 Calcium dyshomeostasis in white matter injury

Elena Alberdi, Asier Ruiz, Carlos Matute

19 Inflammation and white matter injury in animal models of ischemic stroke

Lyanne C. Schlichter, Sarah Hutchings, Starlee Lively

20 Oxidative stress in white matter injury

Hideyuki Yoshioka, Takuma Wakai, Hiroyuki Kinouchi, Pak H Chan

21 Acute Axonal Injury in White Matter Stroke

Jason D. Hinman, S. Thomas Carmichael

Section IV Other white matter injuries

22 Mitochondria disorder and white matter injury

R. Anne Stetler, PhD, Rehana K. Leak, PhD, Zheng Jing, PhD, Xiaoming Hu, PhD, Yanqin Gao, MD, Guodong Cao, PhD, and Jun Chen, MD

23 Heave metal and white matter injury

Yang V. Li

24 Anesthesia and white matter injury

Phillip Vlisides, Zhongcong Xie