Main description:

While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.

Contents:

Part I: Molecular Mechanisms

1. CNS Barriers in Neurotrauma

Adam Chodobski, Brian J. Zink, and Joanna Szmydynger-Chodobska

2. Mechanisms of Cerebral Edema Leading to Early Seizures after Traumatic Brain Injury

Philip H. Iffland II, Gerald G. Grant and Damir Janigro

3. Human Cerebral Blood Flow and Traumatic Brain Injury

David A. Hovda and Thomas C. Glenn

4. Gliovascular Targets in Traumatic CNS Injury

Arjun Khanna, Brian P Walcott, Kristopher T Kahle, Volodymyr Gerzanich, J. Marc Simard

5. Neurovascular Responses to Traumatic Brain Injury

Josephine Lok, Ken Arai, Shu-zhen Guo, Wendy Leung, Takakuni Maki, Deepti Navaratna, Klaus van Leyen, Changhong Xing, and Eng H. Lo

6. The Effects of Intravascular Coagulation and Microthrombosis on Cerebral Perfusion after Brain Trauma

Monisha A. Kumar, Doug H. Smith, and Sherman C. Stein

7. Barriers to Drug Delivery for Brain Trauma

Robert S. B. Clark

8. Angiogenesis and Functional Recovery after Traumatic Brain Injury

Yanlu Zhang, Ye Xiong, Asim Mahmood, Zheng Gang Zhang, and Michael Chopp

9. Vascular Mechanisms in Spinal Cord Injury

Theo Hagg

10. Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury

Kunjan R. Dave, John W. Thompson, Jake T. Neumann, Miguel A. Perez-Pinzon, Hung W. Lin

11. Stem Cells for Neurovascular Repair in CNS TraumaMibel M. Pabon, Travis Dailey, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Sandra Acosta, Yuji Kaneko, Cesar V. Borlongan

12. Vascular Actions of Hypothermia in Brain Trauma

W. Dalton Dietrich and Helen M. Bramlett

Part II: Experimental Models and Methods

13. Vascular Responses in Rodent Models of Traumatic Brain Injury

Xiaoshu Wang, Zhanyang Yu, Zhengbu Liao, Qi Liu, MingMing Ning, Xiaochuan Sun, Josephine M. Lok, Eng H. Lo, Xiaoying Wang

14. SAH Models: Review, New Modification, and Prospective

Sheng Chen, Damon Klebe, Alexander Vakhmyanin, Mutsumi Fujii, John H. Zhang

15. Age and Sex Differences In Hemodynamics In a Large Animal Model of Brain Trauma

William M. Armstead and Monica S. Vavilala

16. Neutrophils as Determinants of Vascular Stability in the Injured Spinal Cord

Alpa Mahuvakar, Sang Mi Lee, Haoqian Zhang, and Linda J. Noble-Haeusslein

17. Blood Biomarkers for Acute CNS Insults: Traumatic Brain Injury and Stroke

Olena Glushakova, Stefania Mondello, Ronald L. Hayes

18. Biomaterials for CNS Injury

Myron Spector and Teck Chuan Lim

19. Isolated Blood Vessel Models for Studying Trauma

Eugene V. Golanov

Part III: Clinical Challenges and Opportunities

20. Managing Edema and Intracranial Pressure in the Intensive Care Unit

Brian Cummings, Phoebe H. Yager, Sarah A. Murphy, Brian Kalish, Chetan Bhupali, Rebecca Bell, Zenab Mansoor, Natan Noviski, and Michael J. Whalen

21. Surgical Management of Traumatic Brain Edema

Takeshi Maeda, Tatsuro Kawamata, Atsuo Yoshino, Yoichi Katayama

22. Optimizing Hemodynamics in the Clinical Setting

Jose Alberto Toranzo and Claudia S. Robertson,

23. Cerebrovascular Autoregulation and Monitoring of Cerebrovascular Reactivity Philip M. Lewis, Marek Czosnyka, Piotr Smielewski, John D. Pickard

24. Cerebrovascular Responses after Pediatric Traumatic Brain Injury

Steven Shein, Nikki Ferguson, and Michael J. Bell

25. Subdural Hematoma in Non-Accidental Head Injury

Jennifer C. Munoz Pareja, Josephine Lok, Natan Noviski, Ann-Christine Duhaime

26. Blood Genomics after Brain Ischemia, Hemorrhage, and Trauma

Da Zhi Liu, Glen C Jickling, Boryana Stamova, Xinhua Zhan, Bradley P Ander and Frank R Sharp

27. Molecular Biomarkers in Neurocritical Care - The Next Frontier

Sherry H-Y Chou and MingMing Ning

28. Bedside Monitoring of Vascular Mechanisms in CNS Trauma: The use of Near Infra-red Spectrpscopy (NIRS) and Transcranial Doppler (TCD)

Sarah Murphy, Brian Cummings, David Boas and Natan Noviski

29. In vivo MRI and MRS of Cerebrovascular Function following Traumatic Brain Injury

Chandler Sours, Rao P Gullapalli