Main description:

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions.
Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

Contents:

ForewordMark T. Nelson
I. Ion channel regulation of vascular tone and blood flow. Changes with hypertension.
I.1. Endothelial cells
I.1.1. Endothelial cell ion channel expression and function in arterioles and resistance arteriesWilliam F. Jackson
I.1.2. Contribution and Regulation of Calcium channels in Endothelial CellsKwong Tai Cheng, Avia Rosenhouse-Dantsker, and Asrar B. Malik
I.1.3. Mitochondrial depolarization in endothelial and other vascular cells and their role in the regulation of cerebral vascular toneDavid W. Busija, Ibolya Rutkai, and Prasad V. Katakam
I.1.4. Ion channels in Hypertension and Control of Blood Flow: Electrical conduction along endothelium of resistance arteriesErik J. Behringer and Steven S. Segal
I.1.5. Ca2+/calmodulin-gated small- and intermediate-conductance KCa channels in cardiovascular regulation: Targets for novel pharmacological treatmentsRalf Koehler. Aida Olivan-Viguera
I.2. Smooth Muscle Cell
I.2.1. Regional Variation in Arterial Myogenic Responsiveness - Links To Potassium Channel Diversity/FunctionMichael A. Hill, Yan Yang, Zahra Nourian, Barry D. Kyle, Kwangseok Hong and Andrew P. Braun
I.2.2. Ion Channel Trafficking and Control of Arterial ContractilityM. Dennis Leo and Jonathan H. Jaggar
I.2.3. Abnormalities of Vascular Ion Channels during HypertensionI.2.4. Kv7 Potassium Channels as Therapeutic Targets in Cerebral VasospasmBharath K. Mani, Lyubov I. Brueggemann, Sarkis Morales-Vidal, Christopher M. Loftus, and Kenneth L. Byron
I.2.5. Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases Fan Zhang, Pin-Lan Li
II. Ion channels in the regulation of cell proliferation, remodeling, hypertrophy and angiogenesis
II.1. Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth MuscleJohn G. McCarron, Susan Chalmers, Calum Wilson & Mairi E. Sandison
II.2. Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors Holly C. Cappelli, Roslin J. Thoppil, Ravi K. Adapala, J. Gary Meszaros, Sailaja Paruchuri, and Charles K. Thodeti
II.3. TRPC and Orai channels in store-operated calcium entry and vascular remodeling
David J Beech, Jing Li, Lynn McKeown, and Hollie L Appleby
II.4. Smooth muscle cell ion channels in pulmonary arterial hypertension: pathogenic role in pulmonary vasoconstriction and vascular remodelingRamon J. Ayon, Haiyang Tang, Ruby A. Fernandez, Ayako Makino, and Jason X.-J. Yuan
III. Ion channel regulation by lipids and channel modifications in metabolic disease
III.1. Physiological roles and cholesterol sensitivity of endothelial inwardly-rectifying K+ channels: specific cholesterol-protein interactions through non annular binding sites Irena Levitan, Sang Joon Ahn, Ibra Fancher, Avia Rosenhouse-Dantsker
III.2. Membrane lipids and modulation of vascular smooth muscle ion channelsAlex M. Dopico, Anna N. Bukiya and Guruprasad Kuntamallappanavar
III.3. Transient receptor potential channels in metabolic syndrome-induced coronary artery diseaseStacey L. Dineen, Zachary P. Neeb, Alexander G. Obukhov, and Michael Sturek
III.4. Mitochondrial ion channels in metabolic diseaseAaron H Truong, Saravanakumar Murugesan, Katia D Youssef, and Ayako Makino
Index