Main description:

Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs.

The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.

Contents:

Chapter 1 Regulatory T Cells and Cancer.....Mary Jo Turk

Chapter 2 Th17 cells in cancer.....Chrystal M. Paulos, Michelle H. Nelson and Xue-Zhong Yu

Chapter 3 Mast cells and immune response in cancer..... Paola Pittoni and Mario P. Colombo

Chapter 4 Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance.....

Paolo Serafini and Vincenzo Bronte

Chapter 5 Immunobiology of Dendritic Cells in Cancer.....Michael R. Shurin, Anton Keskinov and Gurkamal S. Chatta

Chapter 6 Macrophages and Tumor Development.....Suzanne Ostrand-Rosenberg

Chapter 7 Angiogenesis and Immune Suppression in Cancer.....Greg T. Motz and George Coukos

Chapter 8 Tim-3 Regulation of Cancer Immunity.....Kaori Sakuishi and Ana C. Anderson

Chapter 9 Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment......Aimin Jiang, Katherine E. Stagliano, Steven M. Cuss, Ashley Triplett, Chunmei Fu, and Arthur A. Hurwitz

Chapter 10 S100A9, Inflammation, and Regulation of Immune Suppression in Cancer......Thomas Condamine, Indu R. Ramachandran and Dmitry I. Gabrilovich

Chapter 11 IDO in Inflammatory Programming and Immune Suppression in Cancer.....George C. Prendergast, Courtney Smith, Sunil Thomas, Laura Mandik-Nayak, Lisa Laury-Kleintop, Richard Metz and Alexander J. Muller

Chapter 12 Defining the Fate and Function of Effector T cells through Galectin-1 - Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity......Charles J. Dimitroff and Gabriel A. Rabinovich

Chapter 13 Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells......Paulo C. Rodriguez, and Augusto C. Ochoa

Chapter 14 The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment.....Akio Ohta and Michail Sitkovsky

Chapter 15 Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance.....David M. Woods, Andressa Laino, Alejandro Villagra and Eduardo M. Sotomayor

Chapter 16 Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer.....Jeffrey S. Weber