Main description:

The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology.

Contents:

1. Introduction
2. Bone Remodelling & Regulation*
3. Food Intake of Bone Formation
4. Central Control of Bone Mass
5. Neuropeptide Y and Bone Formation
6. Serotonin: The Central Link between Bone Mass and Energy Metabolism
6. Gut Serotonin Bone Formation
7. Gut Serotonin and Osteoporosis
8. Regulation of Bone Resoprtion by PPARGamma
10. Regulation of Energy Metabolism by Bone
11. Bone Marrow Fat and Bone Mass
12. Bone Mass and Energy Metabolism in Humans
13. Regulation of Fertility by Bone
14. Molecular Signaling by Osteocalcin
15. Regulation of Phosphate Metabolism by FGF23
16. The Clinical Use of FGF 23
17. Transcriptional Regulation of the Endocrine Function of Bone