Main description:

This book critically assesses the current state of knowledge on new and important detection technologies, e.g. mass spectrometry, tandem mass spectrometry, biosensor detection and tissue imaging, in connection with toxic chemical and biological agents.

In general, the main topics discussed concern the risks and consequences of chemical and biological agents for human health in general, with special emphasis on all biochemical and metabolic pathways including the reproductive system. The exposome, genetic risks and the environment, various health hazard agents, risk assessment, environmental assessment and preparedness, and analysis of sub-lethal effects at the molecular level are also discussed. In closing, the book provides comprehensive information on the diagnosis of exposure, and on health concerns related to toxic chemical and biological agents.

Contents:

Contents

1. Professor Giovanni Sindona

2. Evaluation of Quality and Safety of Foods by Tandem Mass Spectrometry by Giovanni Sindona and Leonardo Di Donna........................................................................

3. Detection of Biological Warfare Agents Using Biosensors by Joseph H. Banoub, Abanoub Mikhael ....................................................................................

4. Mass Spectrometry Methods for Food Safety/Detection of Toxins in Food by Gianluca Giorgi..................................................................................

5. Fundamentals of Mass Spectrometry-Based Metabolomics by Emilio S. Rivera, Marissa A. Jones, Emma R. Guiberson, Jeremy L. Norris ..............................................

6. Direct Mass Spectrometry as a Practical Analytical Strategy for High Speed, High Throughput Testing by Mark W. Duncan .........................................................

7. Mass Spectrometry in Ecotoxicology by Ksenia J. Groh and Marc J-F Suter.............

8. Matrix-assisted laser desorption/ionization imaging mass spectrometry: technology and

applications by Josiah C. McMillen, William J. Perry, Kavya Sharman, Katerina V. Djambazova, & Richard M. Caprioli .......................................................

9. Risks and Consequences of Hazard Agents to Human Health by Diana Coman Schmid...

10. Bacterial threats to human health and food supply by Vanessa Sperandio ................

11. An overview of male reproductive toxicants: facts and opinions by Charles Pineau.....................................................................................

12. Defense Against Biological Terrorism: Vaccines and their Characterization by Mauro Bologna, Abanoub Mikhael, Ilaria Bologna, Joseph Banoub..............................

13. Environmental Impact of Air Pollution on Human Health in the Annaba region (Algeria) by Aissa Benselhoub, Ali Ismet Kanli...............................................................

14. New insight into Idiopathic Nephrotic Syndrome: Strategy based on Urinary Exosomes by E. Barigazzi, L. Santorelli, W. Morello, F. Raimondo, B. Crapella, L. Ghio, C. Tamburello, G. Montini, M. Pitto...................................................................

15. Synthesis of long-chain esters under continuous flow conditions by Daniela Caputo, Michele Casiello, Amelita Grazia Laurenza, Francesco Fracassi, Caterina Fusco, Angelo Nacci,, Lucia D'Accolti............................................................................

16. Data Independent Acquisition Mass Spectrometry for Proteomic Advances into Isolated Methylmalonic Acidemia by Michele Costanzo, Marianna Caterino, Armando Cevenini, Laxmikanth Kollipara, Olga Shevchuk, Chi D.L. Nguyen, Albert Sickmann Margherita Ruoppolo.............................................................................................

17. Deposition strategies of nano-TiO2 photocatalyst for wastewater applications by Massimo Dell'Edera, Francesca Petronella, Teresa Sibillano, Cinzia Giannini, Angela Agostiano, Maria Lucia Curri, Roberto Comparelli.........................................................

18. Tri-modal MALDI-MS imaging on the same tissue section: Deeper molecular insights of disease by Vanna Denti, Sonia Guarnerio, Andrew Smith, Isabella Piga, Clizia Chinello, Fulvio Magni......................................................................................

19. Fabrication of QDs dimers with sub-nanometer interparticle distance by Carlo Nazareno Dibenedetto, Elisabetta Fanizza, Annamaria Panniello, Angela Agostiano, Maria Lucia Curri, and Marinella Striccoli................................................................................................

20. Mapping Molecular Interactions in the Clostridium difficile Infected Gastrointestinal Tract Using Multimodal Imaging Mass Spectrometry by Emma R. Guiberson, Aaron G. Wexle, William J. Perry, Eric P. Skaar, Richard M. Caprioli, Jeffrey M. Spraggins................................................................................................

21. Detection, Identification and Monitoring of Chemical Warfare Agents a comparison between on-field and in-lab approach by Matteo Guidotti, Massimo C. Ranghieri, Stefano Econdi..................................................................................................

22. New tools for rapid and sensitive detection of water contamination: whole-cell biosensors and cell-free TX-TL systems by Antonia Lopreside, Maria Maddalena Calabretta, Laura Montali, Xinyi Wan, Baojun Wang, Aldo Roda, Elisa Michelini ..........................................................................

23. A Novel Origami Paper-Based Chemiluminescent Biosensor Integrated With A Smartphone Device for Organophosphorus Compounds Detection by L. Montali, M.M. Calabretta, A. Lopreside, M. Guardigli, E. Michelini, A. Roda .......................................................................

24. Solid-phase microextraction combined with microwave-assisted extraction using eco-friendly solvents as a new approach for the analysis of toxic compounds from environmental solid matrices by Attilio Naccarato, Antonella Tassone, Sacha Moretti, Francesca Sprovieri, Nicola Pirrone, Antonio Tagarelli.....................................................

25. Recent advances in MALDI mass spectrometry imaging: a cutting-edge tool for the diagnosis of thyroid nodules by Isabella Piga, Giulia Capitoli, Francesca Clerici, Stefania Galimberti, Fulvio Magni, Fabio Pagni...............................................................................

26. Luminescent Polymeric Nanovectors loaded with Darunavir for treatment of HIV-Associated Neurological Diseases by F. Rizzi, T. Latronico, A. Panniello, V. Laquintana, N. Denora, I. Arduino, A. Fasano, C. M. Mastroianni, E. Fanizza, M. Striccoli, A. Agostiano, G.M. Liuzzi, M. L. Curri, N. Depalo.................................................................

27. Investigation of the N-Glycoproteome in the Urinary Exosomes: Technical Challenges by Technical Challenges by L. Santorelli, E. Barigazzi, M. Pitto, F. Raimondo.............................................................................................................

28. Fluoroquinolones In Water: Removal Attempts By Innovative AOPs by Scrano L., Foti L., Lelario F. .....................................................................

29. Evaluation of Surface Second Harmonic Generation SSHG for Detection of Antibody-Antigen Interactions by AbdelMohsen Soliman...................................................

30. Impact of asbestos-related toxicity on Italian working population: preliminary incidence data from the last 5 years across the whole country by Vinci A, Ingravalle F, Mancinelli S, D'Ercole M, Lucaroni F, Palombi L...............................................................

31. Magnetically Targeted Delivery of Sorafenib through Magnetic Solid Lipid Nanoparticles towards Treatment of Hepatocellular Carcinoma by F. Vischio, N. Depalo, R. M. Iacobazzi, M. P. Scavo, S. Villa, F. Canepa, S. Hee Lee, B. Chul Lee, E. Fanizza, I. Arduino, V. Laquintana, A. Lopalco, A. Lopedota, A. Cutrignelli, M. Striccoli, A. Agostiano, N. Denora, M. L. Curri................................................................................................

32. Identification of Some Organic Solvents During Regular Forensic Determination of Alcohols in Blood and Bioliquids by Igor Winkler, Nataliia Burkun, Iryna Lebedintseva............................................................................