Main description:

Despite significant improvement in the management of patients with chronic kidney disease, the morbidity and mortality remain high. However more is now understood about the hormonal influence on bone and vascular structures, and there have been major advances in the field of bone and mineral metabolism. This has lead to the development of new treatment strategies and agents.

This new second edition reflects the most current thinking and understanding in this fascinating field, as presented by world basic and clinical experts.

Contents:

1. Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD) ; 2. New aspects of normal bone biology ; 3. Osteocytes and mineral metabolism ; 4. Calcium-sensing receptors (CaSRs) in kidney, bone and vessels ; 5. Regulation of parathyroid hormone biosynthesis and gene expression ; 6. Abnormal parathyroid gland function in CKD ; 7. PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor ; 8. Vitamin D metabolism and action in CKD ; 9. Growth factors and cytokines in renal bone disease ; 10. Bone histomorphometry in renal osteodystrophy ; 11. The spectrum of renal osteodystrophy and vascular calcifications in uremia ; 12. Imaging of the skeleton and the joints in CKD ; 13. Non-invasive assessment of vascular calcification and arterial stiffness ; 14. Osteopenia in uremia ; 15. Acidosis and renal bone disease ; 16. Dialysis-associated amyloidosis ; 17. Pathogenesis of vascular calcification: experimental studies ; 18. Clinical consequences of arterial calcifications and soft-tissue calcifications in Chronic Kidney Disease ; 19. Clinical management of vascular and soft tissue calcifications in Chronic Kidney Disease patients ; 20. The role of the skeleton in the pathogenesis of vascular calcification in the Chronic Kidney Disease-Mineral Bone Disorder ; 21. Klotho: bone, kidney, vascular calcifications, and the ageing process ; 22. Physiology and pathology of calcium and magnesium transport ; 23. Phosphatonins in health and disease ; 24. FGF-23 in renal failure ; 25. New vitamin D analogs for chronic kidney disease patients ; 26. Calcimimetics and calcilytics in the treatment of chronic kidney disease-mineral and bone disorder ; 27. Medical therapy in chronic kidney disease ; 28. Chronic kidney disease-mineral and bone disorder (CKD-MBD) in children ; 29. Bone disease in renal transplant recipients ; 30. Imaging and intervention of parathyroid hyperplasia ; 31. Surgical management of secondary hyperparathyroidism ; 32. Morbidity and mortality related to disturbances in mineral metabolism in CKD