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The Molecular Basis of Human Cancer
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Main description:

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.

The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.


Feature:

Written by experts in the field

Updated and revised to include current research
Richly illustrated


Back cover:

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.

The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.


Contents:

Chapter 1
Cancer Epidemiology: Incidence and Etiology of Human Neoplasms
William B. Coleman and Gregory J. Tsongalis

Chapter 2
Essential Concepts and Techniques in Molecular Biology
Claudine L. Lefferts, PhD and Joel A. Lefferts, PhD

Chapter 3
Cancer Genomics
Jonathan R. Pollack

Chapter 4
Cancer Cytogenetics
Thomas Ried, Kerstin Heselmeyer-Haddad, Jordi Camps, and Timo Gaiser

Chapter 5
The Epigenetic Basis of Human Cancer
Thomas Mikeska and Alexander Dobrovic

Chapter 6
Cancer Proteomics
Jeffrey M. Lake and Timothy D. Veenstra

Chapter 7
An Overview of Cancer Genes
Ashley G. Rivenbark, PhD

Chapter 8
Oncogenes and the Initiation and Maintenance of Tumorigenesis
Dean W. Felsher, Constadina Arvanitis, Pavan Bendapudi, and Pavan Bachireddy

Chapter 9
Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors
Luca Grumolato, Ph.D. and Stuart Aaronson, M.D.

Chapter 10
Senescence, Apoptosis, and Cancer
Manjari Dimri and Goberdhan P. Dimri

Chapter 11
Novel Cancer Therapies Targeting Angiogenesis
Monte Willis and Nancy Klauber-DeMore

Chapter 12
Beyond the Primary Tumor: Progression, Invasion, and Metastasis
Danny R. Welch, Ph.D. and Douglas R. Hurst, Ph.D.

Chapter 13
Simple Sequence Mutations
Christophe Béroud and Mireille Claustres
Chapter 14
Single Nucleotide Polymorphisms and Cancer Susceptibility
Richard A. Hubner and Richard S. Houlston

Chapter 16Chromosomes and Chromosomal Instability in Human Cancer
Kazuma Ohyashiki, Masahiko Kuroda, and Junko H. Ohyashiki

Chapter 17
Epigenetic Mechanisms in Cancer Development
José Ignacio Martín-Subero and Manel Esteller

Chapter 18
MicroRNAs and Cancer
Phong Trang, Joanne Weidhaas, and Frank J. Slack

Chapter 19
Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas
Mutlay Sayan and Brooke T. Mossman

Chapter 20
Viral Mechanisms in Human Carcinogenesis
Paul F. Lambert, PhD

Chapter 21
Hormonal Carcinogenesis: The Role of Estrogens
William A. Ricke, Karin Williams, Jalissa Wynder, Ganesh Palapattu, Yuzhuo Wang, Gerald R. Cunha

Chapter 22
Sporadic Cancers
Clemens B. Tempfer and Marc-André Reymond
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Chapter 23
Hereditary Cancer
Zoran Gatalica, MD, DSc, Anatole Ghazalpour, PhD Stan L. Lilleberg, PhD, Jeffrey Swensen, PhD, and Henry T. Lynch, MD

Chapter 24
Retinoblastoma:  Clinical and Molecular Perspectives
Justis P. Ehlers MD and J. William Harbour MD

Chapter 25
Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light
James E. Cleaver

Chapter 26
Hereditary Colorectal Cancer
Sonia S. Kupfer and Nathan A. Ellis

Chapter 27
Lungs
Michael P. Lux, Mayada R. Bani, Peter A. Fasching, and Matthias W. Beckmann

Chapter 28
The Molecular Basis of Prostate Carcinogenesis
Smitha Dutt and Allen C. Gao

Chapter 29
Molecular Basis of Lung Carcinogenesis
Kwun M. Fong, Jill E. Larsen, Casey Wright, Krishna Sriram, Morgan Davidson, Marissa Daniels, Yoshitaka Sekido, Rayleen V. Bowman, Ian A. Yang, and John D. Minna

Chapter 30
The Molecular Basis of Skin Carcinogenesis
Alessia Pacifico, MD, Giovanni Leone, MD, Honnavara N. Ananthaswamy, PhD

Chapter 31
The Molecular Biology of Leukemias
L. Jeffrey Medeiros and Sergej N. Konoplev

Chapter 32
Molecular Mechanisms in Non-Hodgkin Lymphoma
John Hunt, MD, Yuri Fedoriw, MD and William N. Rezuke, Jr., MD

Chapter 33
The Molecular Pathology of Head and Neck Squamous Cell Carcinoma
Laura J. Tafe

Chapter 34
Ovarian Cancer
Amy D. Brockmeyer and Louis Dubeau, MD, PhD

Chapter 35
Molecular Pathology of Bone and Soft Tissue Tumors
José Luis Ordóñez PhD, Daniel Osuna PhD, Juan Madoz-Gúrpide PhD, Enrique de Álava, MD, PhD

Chapter 36
The Molecular Biology of Human Brain Tumors
Daniel Coluccia, Adrienne Weeks, Javier Fandino, Christian Schneider, Christian Smith, and James T. Rutka

Chapter 37
Cancer Drug Discovery and Anticancer Drug Development
James Turkson, PhD

Chapter 38
Heart
Zhuo (Georgia) Chen, PhD, Suresh Ramalingam, MD, and Dong M. Shin, MD

Chapter 39
Targeting Oncoproteins for Molecular Cancer Therapy
Joshua E. Allen and Wafik S. El-Deiry

Chapter 40
Therapeutic Agents that Inhibit Angiogenesis
Francesco Torino, Roberta Sarmiento, Raffaelle Longo, and Giampietro Gasparini

Chapter 41
Small Molecule Inhibitors
Xin Chen, Ph.D. and Jian Jin, Ph.D

Chapter 42
Molecular Detection and Diagnosis of Cancer
Christos Patriotis, Padma Maruvada, and Sudhir Srivastava

Chapter 43
Gene Therapy in the Treatment of Human Cancer
Anand C. Annan, MBBS, Paul B. Fisher, MPh, PhD, Paul Dent, PhD, Gene P. Siegal, MD, PhD, David T. Curiel, MD, PhD

Chapter 44
Personalized Medicine for the Treatment of Human Cancer
Scott A. Turner, PhD and Gregory J. Tsongalis, PhD


PRODUCT DETAILS

ISBN-13: 9781934115183
Publisher: Springer (Springer New York)
Publication date: July, 2016
Pages: 800
Availability: Not yet available
Subcategories: Genetics, Oncology, Pathology

MEET THE AUTHOR

William B. Coleman
Department of Pathology and Laboratory medicine, Curriculum in 
Toxicology, Program in Translational Medicine, UNC Lineberger 
Comprehensive Center, University of North Carolina School of Medicine, 
Chapel Hill, NC

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