Main description:

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.
The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

Contents:

Chapter 1Cancer Epidemiology: Incidence and Etiology of Human NeoplasmsWilliam B. Coleman and Gregory J. Tsongalis
Chapter 2Essential Concepts and Techniques in Molecular BiologyClaudine L. Lefferts, PhD and Joel A. Lefferts, PhD
Chapter 3Cancer GenomicsJonathan R. Pollack
Chapter 4Cancer CytogeneticsThomas Ried, Kerstin Heselmeyer-Haddad, Jordi Camps, and Timo Gaiser
Chapter 5The Epigenetic Basis of Human CancerThomas Mikeska and Alexander Dobrovic
Chapter 6Cancer ProteomicsJeffrey M. Lake and Timothy D. Veenstra
Chapter 7An Overview of Cancer GenesAshley G. Rivenbark, PhD
Chapter 8Oncogenes and the Initiation and Maintenance of TumorigenesisDean W. Felsher, Constadina Arvanitis, Pavan Bendapudi, and Pavan Bachireddy
Chapter 9Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and ReceptorsLuca Grumolato, Ph.D. and Stuart Aaronson, M.D.
Chapter 10Senescence, Apoptosis, and CancerManjari Dimri and Goberdhan P. Dimri
Chapter 11Novel Cancer Therapies Targeting AngiogenesisMonte Willis and Nancy Klauber-DeMore
Chapter 12Beyond the Primary Tumor: Progression, Invasion, and MetastasisDanny R. Welch, Ph.D. and Douglas R. Hurst, Ph.D.
Chapter 13Simple Sequence MutationsChristophe Beroud and Mireille ClaustresChapter 14Single Nucleotide Polymorphisms and Cancer SusceptibilityRichard A. Hubner and Richard S. Houlston
Chapter 16Chromosomes and Chromosomal Instability in Human CancerKazuma Ohyashiki, Masahiko Kuroda, and Junko H. Ohyashiki
Chapter 17Epigenetic Mechanisms in Cancer DevelopmentJose Ignacio Martin-Subero and Manel Esteller
Chapter 18MicroRNAs and CancerPhong Trang, Joanne Weidhaas, and Frank J. Slack
Chapter 19Erionite and Asbestos in the Pathogenesis of Human Malignant MesotheliomasMutlay Sayan and Brooke T. Mossman
Chapter 20Viral Mechanisms in Human CarcinogenesisPaul F. Lambert, PhD
Chapter 21Hormonal Carcinogenesis: The Role of EstrogensWilliam A. Ricke, Karin Williams, Jalissa Wynder, Ganesh Palapattu, Yuzhuo Wang, Gerald R. Cunha
Chapter 22Sporadic CancersClemens B. Tempfer and Marc-Andre ReymondChapter 24Retinoblastoma: Clinical and Molecular PerspectivesJustis P. Ehlers MD and J. William Harbour MD
Chapter 25Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet LightJames E. Cleaver
Chapter 26Hereditary Colorectal CancerSonia S. Kupfer and Nathan A. Ellis
Chapter 27LungsMichael P. Lux, Mayada R. Bani, Peter A. Fasching, and Matthias W. Beckmann
Chapter 28The Molecular Basis of Prostate CarcinogenesisSmitha Dutt and Allen C. Gao
Chapter 29Molecular Basis of Lung CarcinogenesisKwun M. Fong, Jill E. Larsen, Casey Wright, Krishna Sriram, Morgan Davidson, Marissa Daniels, Yoshitaka Sekido, Rayleen V. Bowman, Ian A. Yang, and John D. Minna
Chapter 30The Molecular Basis of Skin CarcinogenesisAlessia Pacifico, MD, Giovanni Leone, MD, Honnavara N. Ananthaswamy, PhD
Chapter 31The Molecular Biology of LeukemiasL. Jeffrey Medeiros and Sergej N. Konoplev
Chapter 32Molecular Mechanisms in Non-Hodgkin LymphomaJohn Hunt, MD, Yuri Fedoriw, MD and William N. Rezuke, Jr., MD
Chapter 33The Molecular Pathology of Head and Neck Squamous Cell CarcinomaLaura J. Tafe
Chapter 34Ovarian CancerAmy D. Brockmeyer and Louis Dubeau, MD, PhD
Chapter 35Molecular Pathology of Bone and Soft Tissue TumorsJose Luis Ordonez PhD, Daniel Osuna PhD, Juan Madoz-Gurpide PhD, Enrique de Alava, MD, PhD
Chapter 36The Molecular Biology of Human Brain TumorsDaniel Coluccia, Adrienne Weeks, Javier Fandino, Christian Schneider, Christian Smith, and James T. Rutka
Chapter 37Cancer Drug Discovery and Anticancer Drug DevelopmentJames Turkson, PhD
Chapter 38HeartZhuo (Georgia) Chen, PhD, Suresh Ramalingam, MD, and Dong M. Shin, MD
Chapter 39Targeting Oncoproteins for Molecular Cancer TherapyJoshua E. Allen and Wafik S. El-Deiry
Chapter 40Therapeutic Agents that Inhibit AngiogenesisFrancesco Torino, Roberta Sarmiento, Raffaelle Longo, and Giampietro Gasparini
Chapter 41Small Molecule InhibitorsXin Chen, Ph.D. and Jian Jin, Ph.D
Chapter 42Molecular Detection and Diagnosis of CancerChristos Patriotis, Padma Maruvada, and Sudhir Srivastava
Chapter 43Gene Therapy in the Treatment of Human CancerAnand C. Annan, MBBS, Paul B. Fisher, MPh, PhD, Paul Dent, PhD, Gene P. Siegal, MD, PhD, David T. Curiel, MD, PhD
Chapter 44Personalized Medicine for the Treatment of Human CancerScott A. Turner, PhD and Gregory J. Tsongalis, PhD