Established as a definitive reference for the IVF clinic, the fifth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including GnRH agonist triggering, segmentation of IVF treatment, uterus transplantation, and risk and safety management. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.
The beginnings of human in vitro fertilization. Robert Edwards and the thorny path to the birth of Louise Brown: A history of IVF and ET. Quality management in reproductive medicine. Lifestyle, periconception, and fertility. The environment and reproduction. Indications for IVF treatment: From diagnosis to prognosis. Initial investigation of the infertile couple. Prognostic testing for ovarian reserve. Drugs used for ovarian stimulation: Clomiphene citrate, aromatase inhibitors, metformin, gonadotropins, gonadotropin-releasing hormone analogs, and recombinant gonadotropins. The role of FSH and LH in ovulation induction: Current concepts. Endocrine characteristics of ART cycles. The use of GnRH agonists and the efficiency of IVF. GnRH antagonists in ovarian stimulation for IVF. GnRH agonist triggering. Segmentation of IVF treatment. The use of ovarian reserve biomarkers to tailor ovarian stimulation for IVF. Monitoring ovarian response in assisted reproduction (IVF and ICSI). Oocyte collection. Luteal phase support (LPS) in ART. Treatment strategies in assisted reproduction for the poor responder patient. Repeated implantation failure. Ultrasonography in assisted reproduction. Sperm recovery techniques: Clinical aspects. Processing and cryopreservation of testicular sperm. Embryo transfer technique. Regimes for frozen-thawed embryo transfer. Anesthesia for in vitro fertilization. Medical considerations of single embryo transfer. Endometriosis and ART. PCOS and assisted reproduction. Management of hydrosalpinx. Fertility preservation strategies. Uterus transplantation. Viral disease and ART. Severe ovarian hyperstimulation syndrome. Bleeding, severe pelvic infection, and ectopic pregnancy. Iatrogenic multiple pregnancies: The risk of ART. The evolving role of the ART nurse: A contemporary review. Patient support in the ART program. The relationship between stress and in vitro fertilization outcome. The impact of legislation and socioeconomic factors in the access to and global practice of ART. Religious perspectives in human reproduction. Risk and safety management.