Main description:

This edited volume focuses on the interplay between sleep and circadian rhythms with health, aging and longevity. Sleep is absolutely important for human health and survival, as insufficient sleep is associated with a plethora of conditions, including the poor quality of life, onset of several diseases, and premature death. The sleep-wake cycle is an evolutionary conserved neurobiological phenomenon, and is a prominent manifestation of the biological clocks localised in the suprachiasmatic nucleus (SCN). Understanding bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, especially in the context of modern lifestyle where sleep is often out of phase with the internal body clocks, social jetlag, artificial lights and so on.

The 25 chapters by leading researchers and experts from 11 countries are arranged into seven sections: understanding sleep and clock interlink in health and longevity; sleep, aging and longevity; clock, aging and longevity; melatonin, sleep and clock; genetic regulation of sleep and clock; therapeutic interventions in sleep disorders and clock misalignment; and experimental models to study sleep and clocks in aging and longevity.

This book is useful for advanced undergraduate and graduate students, and researchers, educators, and other biomedical professionals.

Contents:

Part I: UNDERSTANDING SLEEP AND CLOCK INTERLINK IN HEALTH AND LONGEVITY

Chapter1: Sleep and circadian clock : Novel players in health impacts and Aging.

Anita Jagota, Neurobiology and Chronobiology Laboratory, Department of Animal Biology, School of Life Sciences,

Univ of Hyderabad, India. E-mail: ajsl@uohyd.ac.in

Chapter2: Cells and circuits of the suprachiasmatic nucleus and the control of circadian behaviour and sleep.

Michael Hastings, Nicola Smyllie and Andrew Patton, Division of Neurobiology,

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH,

UK. E-mail: mha@mrc-lmb.cam.ac.uk

Chapter3: Circadian roles in sleep.

Han Wang, Center for Circadian Clocks, Soochow University, China. E-mail: han.wang88@gmail.com

Chapter 4: Age-related decline in the central circadian clock.

Takahiro J. Nakamura, Laboratory of Animal Physiology, Department of Life Sciences, School of Agriculture, Meiji

University, Kawasaki, Japan. E-mail: takahiro@meiji.ac.jp

Chapter 5: Cellular clocks in senescent cells.

Yasukazu Nakahata, Department of Neurobiology and Behavior, Graduate School of Biomedical Sciences, Nagasaki

University, Nagasaki Japan. E-mail: yasu-nakahata@nagasaki-u.ac.jp

Part II: SLEEP, AGING AND LONGEVITY

Chapter 6: Optimum sleep for healthy aging.

Birender Mallik, School of Life Sciences, JNU, Delhi, India. E-mail: remsbnm@yahoo.com

Chapter 7: Healthy brain aging and longevity; the harmony of natural products, APOE polymorphism and melatonin. Ranil De Silva, Genetic Diagnostic and Research Laboratory, Department of Anatomy, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. E-mail: ranil@sjp.ac.lk

Chapter 8: Role of sleep in imprinting healthy aging.

Kamlesh K Gulia, Division of Sleep Research Biomedical Technology Wing, SCTIMST, Thiruvananthapuram, Kerala,

India. E-mail: kkguliak@hotmail.com

Chapter 9: Sleep, aging and cognitive decline.

Krishna Melnattur, Ashoka University Delhi, India. E-mail: krishna.melnattur@gmail.com

Part III: CLOCK, AGING AND LONGEVITY

Chapter 10: How non-photic cues for the circadian time system matter in healthy aging.

Maristela de Oliveira Poletini, Departamento de Fisiologia e Biofisica (ICB), Universidade Federal de Minas Gerais-

UFMG, Brasil. E-mail: mopoleti@gmail.com

Chapter 11: Pineal gland physiology and aging-related alterations in the circadian timing system. Seithikurippu R. Pandi-Perumal and Vijay, Somnogen Canada Inc. E-mail: pandiperumal2021@gmail.com

Chapter 12: Conscripting the age-factors that persuade or dissuade neurodegeneration in basal ganglia. Phalguni Alladi NIMHANS, Bangalore, India. E-mail: alladiphalguni@gmail.com

Part IV : MELATONIN, SLEEP AND CLOCK

Chapter 13: Melatonin, infection and aging.

Yaoyao Xia, Univ. of Chinese Academy of Sciences Beijing, China. E-mail: yaoyaoxia2018@126.com

Chapter 14: Melatonin as a chronobiotic and cytoprotector in healthy aging.

Daniel Cardinali, Pontifical Catholic-University of Argentina, South America. E-mail: daniel_cardinali@uca.edu.ar

Chapter 15: Melatonin: A saga of health and longevity.

Chandana Haldar and Sameer Gupta, Dept. Zoology, BHU, India. E-mail: chaldar2001@yahoo.com Part V: GENETIC REGULATION OF SLEEP AND CLOCK

Chapter 16: Circadian rhythm manipulations : implications on behavioral restoration in CNS insults. Bindu Kutty, NIMHANS, Bangalore, India. E-mail: bindu.nimhans@gmail.com

Chapter 17: Epigenetic basis of altered circadian and sleep cycle induced effects on aging and longevity. Arvind Kumar and Sumana Chakravarty, CCMB, Hyderabad, India. E-mail: akumar@ccmb.res.in

Chapter 18: Chronotype and its relation to healthy aging.

Meenakshi Sinha, Department of Physiology, AIIMS Raipur, India. E-mail: sinham66@aiimsraipur.edu.in

Part VI : CHRONOPHARMACOLOGY, SLEEP AND AGING
Chapter 19: Timing anti-aging interventions.

Victoria Acosta-Rodriguez, Department of Neuroscience UT Southwestern Medical Center, Dallas, USA. E-mail: victoria.acosta@utsouthwestern.edu

Chapter 20: Physical exercise and circadian rhythms in humans and nocturnal rodents. Yujiro Yamanaka, Hokkaido University, Sapporo, Japan. E-mail: y-yu2ro@edu.hokudai.ac.jp

Chapter 21: Circadian rhythms and time-restricted eating in health and longevity.
Gurcharan Kaur, GNDU, Amritsar, India. E-mail: kgurcharan.neuro@yahoo.com

Chapter 22: Achieving healthy aging in the light polluted world.

Krystyna Skwarlo-Sonta, University of Warsaw, Poland. E-mail: kss25@biol.uw.edu.pl

Chapter 23: Disruptions of circadian rhythms and sleep/wake cycles in neurologic disorders.

Randy J Nelson and William Walker, Hazel Ruby McQuain Chair for Neurological Research, Department of

Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, USA. Email: randy.nelson@hsc.wvu.edu

Part VII: EXPERIMENTAL MODELS TO STUDY SLEEP AND CLOCKS IN AGING AND LONGEVITY

Chapter 24: Experimental models to study sleep and clocks in aging and longevity.

Jini Naidoo, Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia,

Email : naidoo@pennmedicine.upenn.edu