Main description:

Summarizes insulin and the closely related IGF-1 receptor signaling.

Depicts concepts of insulin resistance.

Highlights the importance of conserved brain insulin signaling for brain function, metabolism and behavior

Describes potential behavioral and pharmacological approaches to support brain insulin signaling

Contents:

1 Molecular mechanisms of brain insulin signaling

2 Insulin/IGF signaling in early brain development

3 Insulin signaling modulates neuronal metabolism

4 Regulation of glial function by insulin peptides

5 Neuroendocrine interactions in the control of glucose- and energy homeostasis

6 Hypothalamic neuronal circuits are modulated by insulin and impact metabolism

7 Insulin and brain reward systems

8 The impact of insulin on brain serotonergic system: consequences on diabetes-associated mood disorders

9 Organ cross-talk regulates (brain) insulin action

10 Insulin resistance as a risk factor for Alzheimer's disease

11 Brain insulin action in the control of metabolism in humans

12 Impact of dietary and exercise interventions on brain insulin action and brain function

13 Pharmacological and surgical interventions to improve brain insulin resistance