Main description:

Personalized and Stratified Therapy in Epilepsy highlights the individualized- and subgroup-based approaches in diagnosing, treating, and monitoring epilepsy. Whereas the term 'personalized medicine' is used to describe the focus on individual patients, 'stratified medicine' refers to the definition of population subgroups based on estimates of their differences in the etiology and prognosis of epilepsy, or response to treatment. The book describes the various aspects of personalized and stratified approaches in epilepsy, the potential of these approaches to improve the cost-effectiveness of epilepsy treatment, and barriers to their implementation. The book assists clinicians in rationally choosing the required diagnostic and treatment means for their patients, out of the abundance of available technologies and products. By doing so, they will provide better care, mitigating adverse events, expediting the reach of effective treatment, and reducing costs. The target audience is anyone involved in developing and delivering diagnostic means and treatment for people with epilepsy, including epileptologists, other neurologists, neurosurgeons, pharmacists, nurses, technicians, geneticists, researchers

Contents:

Section 1. Diagnosis 1. Classification 2. Seizures semiology 3. Genetic testing 4. Electrophysiological studies 5. Imaging

Section 2. Drug treatment 6. When to start AEDs 7. Antiepileptic drug treatments in children 8. Treating women with epilepsy 9. Antiepileptic drugs in the elderly 10. When to stop treatment: individualized 11. Pharmacogenetics in AED treatment 12. Between-patient variability in the concentrations of antiepileptic drugs 13. Drug resistance: predicting who will respond

Section 3. Non-pharmacological treatments 14. Pre-surgical evaluation 15. Adult tailored surgical aspects 16. Pediatric tailored surgical aspects 17. Neurostimulation

Section 4. Miscellaneous 18. Status epilepticus 19. SUDEP 20. Monitoring sensors 21. Psychiatric co-morbidity 22. Neuropsychological evaluation 23. Patient education

Section 5. Frontiers/research 24. Seizures prediction 25. Epilepsy biomarkers 26. Can we personalize AED development? 27. Invasive monitoring research 28. New treatment devices