Main description:

This book discusses the role of oxidative stress in human reproduction with a focus on men's health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction .

The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men's health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.

Contents:

Content:

1. Oxidative stress and toxicity in reproductive biology and medicine: Historical

perspectives and future horizons in male fertility.............................................

Ralf Henkel

2. Reactive Oxygen Species in the Reproductive System: Sources and

Physiological Roles....................................................................................

Anandan Das and Shubhadeep Roychoudhury

3. Pathological Roles of Reactive Oxygen Species in Male Reproduction....................

Saptaparna Chakraborty and Shubhadeep Roychoudhury

4. Molecular Interactions Associated with Oxidative Stress Mediated Male

Infertility: Sperm and Seminal Plasma Proteomics...........................................

Manesh Kumar Panner Selvam, Damayanthi Durairajanayagam, Suresh C. Sikka

5. Unraveling the Molecular Impact of Sperm DNA Damage on

Human Reproduction...............................................................................

Renata Finelli, Bruno P. Moreira, Marco G. Alves, Ashok Agarwal

6. Role of Infection and Leukocytes in Male Infertility..........................................

Shubhadeep Roychoudhury, Sandipan Das, Shatabhisha Roychoudhury,

Ashok Agarwal, Ralf Henkel

7. Bacteriospermia and Male Infertility: Role of Oxidative Stress............................

Sandipan Das, Shubhadeep Roychoudhury, Anwesha Dey, Niraj Kumar Jha,

Dhruv Kumar, Shatabhisha Roychoudhury, Petr Slama, Kavindra Kumar Kesari

8. Oxidant-Sensitive Inflammatory Pathways and Male Reproductive Functions.........

Sulagna Dutta, Pallav Sengupta, Srikumar Chakravarthi

9. Oxidative Stress and Idiopathic Male Infertility...............................................

Pallav Sengupta, Shubhadeep Roychoudhury, Monika Nath and Sulagna Dutta

10. Oxidative Stress and Varicocele-Associated Male Infertility...............................

Terence Chun-Ting LAI, Shubhadeep Roychoudhury and Chak-Lam CHO

11. Oxidative Stress in Men with Obesity, Metabolic Syndrome and Type 2

Diabetes Mellitus: Mechanisms and Management of Reproductive Dysfunction.......

Kristian Leisegang

12. Metabolic dysregulation and sperm motility in male infertility............................

Sujata Maurya, Kavindra Kumar Kesari, Shubhadeep Roychoudhury,

Jayaramulu Kolleboyina, Niraj Kumar Jha, Saurabh Kumar Jha, Ankur Sharma,

Arun Kumar, Brijesh Rathi, Dhruv Kumar

13. Tale of viruses in male infertility..................................................................

Shreya Das, Arunima Mondal, Jayeeta Samanta, Santanu Chakraborty,

Arunima Sengupta

14. Pathogenesis of Viral Infections and Male Reproductive Health:

An Evidence-Based Study...........................................................................

Diptendu Sarkar, Shubham Dutta, Shubhadeep Roychoudhury, Preethi Poduval,

Niraj Kumar Jha, Paltu Kumar Dhal, Shatabhisha Roychoudhury

and Kavindra Kumar Kesari

15. Sperm redox system equilibrium: Implications for fertilization and male fertility......

Lauren Hamilton, Richard Oko, Antonio Miranda-Vizuete, Peter Sutovsky