Main description:

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicological testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the nervous system, is the sixth volume of a set pre pared under the sponsorship of the International Life Sciences Insti tute (ILSI).

Contents:

General.- Microvasculature in Experimental Glioma and Developing Brain, Rat.- Experimental Allergic Encephalomyelitis, Rat.- Effects of Neurotoxins.- Neurotoxic Effects of Pyridoxine (Megavitaminosis B6), Rat.- Neurotoxic Effects of Doxorubicin, Rat.- Neurotoxic Effects of Clinoquinol, Mouse.- Neurotoxic Effects of Hexacarbons (n-Hexane, Methyl-n-Butylketones; 2,5-Hexane-Dione; 1,4-Diketones).- Organophosphorus Ester-Induced Delayed Neuropathy, Rat.- Neurotoxic Effects of Ethidium Bromide, Rat.- Neurotoxic Effects of 6-Aminonicotinamide, Mouse.- Neurotoxic Effects of Trimethyltin.- Neurotoxic Effects of Lysolecithin, Mouse, Rat.- Neurotoxicity of Perhexiline Maleate in Rats.- Cycloleucine Encephalopathy, Rats and Mice.- Neurotoxic Effects of Amoscanate, Rat.- Neurotoxic Effects of 2-Chloroprocaine and Other Local Anesthetics, Rat.- Systemic Degenerative Disorders of Primary Sensory Neurons in Rats Induced by 4-Hydroxyaminoquinoline 1-Oxide.- Inorganic Mercury Poisoning, Rat.- Tellurium Poisoning, Rat.- Cadmium Poisoning, Rat.- Neoplasms.- Benign and Malignant Neoplasms, Meninges, Rat.- Malignant Reticulosis, Rat.- Gliomas, Mouse.- Lipoma, Brain, Mouse.- Gliomas, Rat.- Peripheral Nerve Sheath Tumors, Rat.- Schwannomas (Induced) Cranial, Spinal, and Peripheral Nerves, Rat.- Malignant Melanotic Schwannomas Induced by 1,1-Dimethylhydrazine, European Hamster.- Cardiac Neurilemmoma, Rat.- Infections.- Parvovirus Infection, Rat.- Encephalomyelitis, Theiler's Virus, Mouse.- Mouse Hepatitis Virus Infection, Brain, Mouse.- Lymphocytic Choriomeningitis, Mouse.- Encephalitozoonosis, Central Nervous System, Rat, Mouse.- Toxoplasmosis, Nervous System, Mouse and Hamster.- Disorders: Inherited or of Unknown Etiology.- Spontaneous Radiculoneuropathy, Aged Rats.- Peripheral Neuropathy in the Mutant Syrian Hamster.- Abberrant Synaptic Development in Mutant "Weaver" Mice.