Main description:

These proceedings focus on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.

Contents:

Preface; X. Shi, et al. Molecular mechanisms of metal-induced toxicity and carcinogenesis; S. Wang, X. Shi. Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes; S. Dong, et al. Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2) exposed to cadmium chloride; P.B. Tchounwou, et al. Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells; C. Huang, et al. Lead-related effects on rat fibroblasts; I. Ivo, et al. In vivo reduction of chromium (VI) and its related free radical generation; K.J. Liu, X. Shi. Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2); P.B. Tehounwou, et al. Combining Drosophila melanogaster somatic-mutation-recombination and electron-spin-resonance-spectroscopy data to interpret epidemiologic observations on chromium carcinogenicity; A.J. Katz, et al. Carcinogenic potential and genomic instability of beryllium sulphate in BALB/c-3T3 cells; N. Keshava, et al. Cr9VI) induces cell growth arrest through hydrogen peroxide-mediated reactions; Z. Zhang, et al. Comparison of roles of three mitogen-activated protein kinases induced by chromium (VI) and cadmium in non-small-cell lung carcinoma cells; S.-M. Chuang, J.-L. Yang. Differential zinc and DNA binding by partial peptides of human protamine HP2; W. Bal, et al. Reduction of CR (VI) by cysteine: significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates; G. Quievryn, et al. Transactivation of RARE and GRE in the cellular response to arsenic; C. Huang, et al. Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titaniumbase implant alloy degradation; N.J. Hallab, et al. Arsenic contamination of groundwater and prevalence of arsenical dermatosis in the Hetao plain area, Inner Mongolia, China; X. Guo, et al. Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo; C. Huang, et al. Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene; D. Bagchi, et al. Carcinogenic metals and NF- B activation; F. Chen, et al. Effect of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest; T. O'Brien, et al. Cell Apoptosis induced by carcinogenic metals; F. Chen, et al. Gene expression profile in response to chromium-induced cell stress in A549 cells; J. Ye, X. Shi. Cr9VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions; Y. Qian, et al. Molecular biology of nickel carcinogenesis; M. Costa, et al. Model reactions of Cr(VI) with DNA mediated by thiol species; D. Krepkiy, et al. On the mechanism of Cr(VI)-induced carcinogenesis: dose dependence of uptake and cellular responses; K. Liu, et al.