Main description:

This special issue of Molecular and Cellular Biochemistry contains twenty-two selected research papers and reviews from a total of one hundred and ten presentations given at the 12th International Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to Cancer, held in Cancun, Mexico, May 10-14, 1997. The Symposium was hosted by the Sociedad Mexicana de Bioquimica and was sponsored by the University of North Texas Health Science Center, Fort Worth, TX, USA.
This volume provides a state-of-the-art source of information for basic scientists and clinicians who are interested in the molecular, biochemical, and cellular aspects of protein-(ADP-ribose) transfer reactions in human health and disease.

Contents:

1. Poly ADP-Ribosylation: A DNA Break Signal Mechanism; F.R. Althaus, et al. 2. Measurement of Poly (ADP-ribose) Glycohydrolase Activity by High Resolution Polyacrylamide Gel Electrophoresis: Specific Inhibition by Histones and Nuclear Matrix Proteins; G. Pacheco-Rodriguez, R. Alvarez-Gonzalez. 3. Regulatory Mechanisms of Poly (ADP-Ribose) Polymerase; R. Alvarez-Gonzalez, et al. 4. Poly (ADP-Ribose) Polymerase: A Guardian of the Genome that Facilitates DNA Repair by Protecting Against DNA Recombination; S. Chatterjee, et al. 5. Trans-Dominant Inhibition of Poly (ADP-Ribosyl)ation Potentiates Alkylation-Induced Shuttle-Vector Mutagenesis in Chinese Hamster Cells; J. Tatsumi-Miyajima, et al. 6. Clostridial Toxins: Molecular Probes of Rho-Dependent Signaling and Apoptosis; D.A. Bobak. 7. Role of Brefeldin A-Dependent ATP-Ribosylation in the Control of Intracellular Membrane Transport; M.G. Silletta, et al. 8. A Dual Approach in the Study of Poly(ADP-Ribose) Polymerase: In Vitro Random Mutagenesis and Generation of Deficient Mice; C. Trucco, et al. 9. The RT6 (ART2) Family of ADP-Ribosyltransferases in Rat and Mouse; R. Bortell, et al. 10. Mapping the Role of NAD Metabolism in Prevention and Treatment of Carcinogenesis; E.L. Jacobson, et al. 11. Molecular Heterogeneity and Regulation Poly(ADP-Ribose) Glycohydrolase; J.-C. Ame, et al. 12. Niacin Deficiency Increases the Sensitivity of Rats to the Short and Long Term Effects of Ethylnitrosourea Treatment; A.C. Boyonoski, et al. 13. Structures and Activities of Cyclic ADP-Ribose, NaADP and their Metabolic Enzymes; H.C. Lee, etal. 14. Identification of the Archaeal NMN Adenylytransferase Gene; N. Raffaelli, et al. 15. Functional Analysis of Poly (ADP-Ribose) Polymerase in Drosophila Melanogaster; M. Miwa, et al. 16. Characterization of NAD: Arginine ADP-Ribosyltransferases; J. Moss, et al. 17. The CD38 Cyclic ADP-Ribose Signaling System in Insulin Secretion; H. Okamoto. 18. Newly Discovered Antiinflammatory Properties of the Benzamides and Nicotinamides; R.W. Pero, et al. 19. Poly(ADP-ribose) Turnover in Quail Myoblast Cells: Relation Between the Polymer Level and its Catabolism by Glycohydrolase; E.B. Affar, et al. 20. Involvement of PARP and Poly(ADP-ribosyl)ation in the Early Stages of Apoptosis and DNA Replication; C.M. Simbulan-Rosenthal, et al. 21. Function of Poly(ADP-ribose) Polymerase in Response to DNA Damage: Gene-Disruption Study in Mice; M. Masutani, et al. 22. Activation of Toxin ADP-Ribosyltransferases by Eukaryotic ADP-Ribosylation Factors; J. Moss, M. Vaughan.