Main description:

The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the preprocessing of clinical data to the development of mathematical equations, their numerical solution, and both in-vivo and in-vitro validation. They discuss the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are presented. This book is addressed to all scientists interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system.

Contents:

1 Cardiac Arrhythmias: Mechanistic Knowledge and Innovation from Computer Models. Natalia A. Trayanova and Patrick M. Boyle.- 2 Discrete Mechanical Modeling of Mechanoelectrical Feedback in Cardiac Tissue: Novel Mechanisms of Spiral Wave Initiation. Louis D. Weise and Alexander V. Panfilov.- 3 Multiscale Modelling of Cardiac Perfusion. Jack Lee, Andrew Cookson, Radomir Chabiniok, Simone Rivolo, Eoin Hyde, Matthew Sinclair, Christian Michler, Taha Sochi and Nicolas Smith.- 4 Using image-based CFD to investigate the intracardiac turbulence. C. Chnafa, S. Mendez, R. Moreno and F. Nicoud.- 5 Multiscale Modeling of Sickle Cell Anemia. Huan Lei and George Em Karniadakis.- 6 A three-dimensional continuum model of active contraction in single cardiomyocytes. Alessio Gizzi, Ricardo Ruiz-Baier, Simone Rossi, Aymen Laadhari, Christian Cherubini, and Simonetta Filippi.- 7 On the Assumption of Laminar ow in Physiological Flows: Cerebral Aneurysms as an Illustrative Example. Oyvind Evju and Kent-Andre Mardal.- 8 Effects of poroelasticity on fluid-structure interaction in arteries: a computational sensitivity study. M. Bukac, I. Yotov, R. Zakerzadeh, P. Zunino.- 9 Personalized Anatomical Meshing of Human Body with Applications. Yuri Vassilevski, Alexander Danilov, Yuri Ivanov, Sergey Simakov and Timur Gamilov.