Metastatic Disease of the Nervous System begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system. The largest section of the volume comprehensively reviews all aspects of brain metastases, from clinical, radiological and neuropathological manifestations to the roles of surgery, radiation, systemic and palliative therapy in their management; the complications of these interventions are also discussed. The clinical manifestations, diagnosis, and treatment of leptomeningeal, dural, spinal epidural, and plexus metastases are also covered in detail.
Section I. Overview 1. Overview of metastatic disease of the central nervous system Section II. Brain Metastases 2. Brain metastases: Epidemiology 3. Pathogenesis and biology 4. Role of the blood-brain barrier in metastatic disease of the central nervous system 5. Metastatic diseases of the central nervous system - neuropathological aspects 6. Brain metastasis: Clinical manifestations, symptom management and palliative care 7. Brain metastases: Neuroimaging 8. The role of surgery for brain metastases from solid tumors 9. Brain metastases: Fractionated whole brain radiotherapy 10. Brain metastases: Radiosurgery 11. Systemic therapy for brain metastases 12. Neurocognitive aspects of brain metastasis Section III. Other Nervous System Metastases 13. Leptomeningeal metastasis 14. Intracranial dural, calvarial and skull base metastases 15. Epidural and intramedullary spinal metastasis: Clinical features and role of fractionated radiotherapy 16. Management - spinal metastases 17. Plexus and peripheral nerve metastasis