Main description:

Structure and biosynthesis of mammalian peroxidases

Reactivity of hypohalous acids with biological substrates

Peroxidases in innate immunity

Peroxidases in human pathology

Modulation of peroxidase-induced biological damage

Contents:

SECTION 1: INTRODUCTION TO MAMMALIAN HEME PEROXIDASES
Structure, function, phylogeny of heme peroxidases
Biosynthesis of MPO and other heme peroxidases
Peroxidasin structure and function
SECTION 2: REACTIVITY OF PEROXIDASE OXIDANTS
Reactivity of peroxidase oxidants with proteins and proteoglycans
Reactivity of peroxidase with nucleic acids, RNA and DNA
Reactivity of peroxidase oxidants with lipids - modification and signaling
Role of MPO in the modification of lipoproteins (LDL and HDL)
Regulation of cellular signaling and survival by peroxidase oxidants
Global profiling of cell responses to peroxidase oxidants
SECTION 3: PEROXIDASES IN INNATE IMMUNITY
MPO and immune cell recruitment and activation
Role of MPO in extracellular trap release by neutrophils
Imaging HOCl production by neutrophils
How microbes combat reactive chlorine species
Priming the innate immune system to combat respiratory disease
SECTION 4: PEROXIDASES IN PATHOLOGY
Imaging the reactivity of MPO in vivo
Role of MPO in vascular dysfunction and signaling
MPO in ischemic heart disease
Role of MPO in neurodegenerative disease
Role of MPO in kidney disease
Role of peroxidases in respiratory disease
Role of peroxidasins in disease
SECTION 5: PREVENTION OF MPO INDUCED DAMAGE
Design and functionality of MPO inhibitors
Modulation of disease using MPO inhibitors
Novel peroxidase inhibitory protein "SPIN" with broad target specificity
Selenium and resistance to oxidative enzyme inactivation