Main description:

Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy,  ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail.
 
Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.

Feature:

Presents strengths and limitations of ablative devices

Covers patient selection, treatment strategy, and outcomes including safety concerns

Provides insight into the latest clinical applications of image-guided diagnosis and treatment

Back cover:

Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy,  ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail.
 
Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.

Contents:

Part I
Scientific Foundation for the Focal Therapy Concept

Chapter 1
Focal Therapy in Other Genitourinary Systems: Renal Cell Carcinoma
Joseph A. Graversen and Jaime Landman

Chapter 2
Changing Landscape of Prostate Cancer Favoring Low Risk Prostate Cancer: Implications for
Active Surveillance Versus Focal Therapy
Byron H. Lee,  Peter R. Carroll, and  Eric A. Klein

Chapter 3
Active Surveillance and Focal Therapy: A European Perspective
Hendrick Van Poppel and Steven Joniau

Chapter 4
Pathologic Basis for Focal Therapy: Understanding Cancer Grade, Volume and Spatial Location
Thomas J. Polascik, Arnauld Villers, Thomas M. Wheeler,   David G. Bostwick, Rodolfo Montironi,  Pierre Nevoux, and Vladimir Mouraviev

Chapter 5
Identifying the Index Lesion
Markos Karavitakis, Mark Emberton, and Hashim Uddin Ahmed

Chapter 6
Molecular Identification of the Indolent Versus Lethal Tumor
G.H.J.M. Leyten and J.A. Schalken

Part II
Advances in Prostate Biopsy Technique

Chapter 7
Biopsy Strategies to Detect Small Prostate Cancers
Ryan Berglund and J. Stephen Jones

Chapter 8
3-D Image-guided Mapping Biopsy for Defining Spatial Distribution of Prostate Cancer
Samuel Clark Berngard, Kyle O. Rove, Jens Rassweiler, Oliver Kalthoff, Marcel Hruza, and
E. David Crawford

Chapter 9
Stereotactic, Image-guided Robotic Biopsy
Osamu Ukimura and André Luis de Castro Abreu

Chapter 10
Multimodality MRI-guided Targeting
Arnauld Villers and Adil Ouzzane

Chapter 11
Quality Assurance in Prostate Biopsy Sampling, Processing, and Reporting: A New Pathologic Paradigm for Prostate Cancer Diagnosis
David G. Bostwick

Part III
Functional and Molecular Imaging

Chapter 12
Contrast-enhanced Ultrasonography
M. Smeenge, M. Mischi, M.P. Laguna, J.J.M.C.H. de la Rosette and H. Wijkstra

Chapter 13
Prostate Elastrography
Stephen Rosenzweig, Liang Zhai, and Kathryn R. Nightingale

Chapter 14
Multi-parametric Magnetic Resonance Imaging Approaches in Focal Prostate Cancer Therapy
Sadhna Verma, Michael A.S. Lamba, Daniel B. Vigneron, Adam Jung, and John Kurhanewicz

Chapter 15
Nanomedicines for Diagnosis and Treatment of Prostate Cancer
Nazila Kamaly, Archana Swami, Ryan Wagner, and Omid Cameron Farokhzad

Chapter 16
New Horizons in Molecular Imaging of Prostate Cancer
Baris Turkbey and Peter L. Choyke

Part IV
Focal Therapy Nomenclature and Patient Selection

Chapter 17
Prostate Focal Therapy: Definitions and Common Terminology
John F. Ward

Chapter 18
Selection Criteria for Focal Therapy of Prostate Cancer
Vladimir Mouraviev and Thomas J. Polascik

Chapter 19
Standardization of Focal Therapy Protocols
Louise Dickinson, Hashim Uddin Ahmed, and Mark Emberton
Part V
Novel Thermoablation Technologies for Focal Therapy

Chapter 20
High Intensity Focused Ultrasound
Satoru Muto and Shigeo Horie

Chapter 21
Photodynamic Therapy for Early Prostate Cancer
Caroline M. Moore and Mark Emberton

Chapter 22
MRI-guided Laser Ablation for Localized Prostate Cancer
Uri Lindner and John Trachtenberg

Chapter 23
Cell Electroporation Mechanisms and Pre-clinical Foundation for Focal Therapy
Mark V. Ortiz and Rafael V. Davalos

Chapter 24
Histotripsy
William W. Roberts

Chapter 25
Cryoablation
David A. Levy and J. Stephen Jones

Chapter 26
Optimizing Ablative Therapy: Manipulating the Microenvironment
John M. Baust, Kimberly Santucci, Anthony Robilotto, Andrew A. Gage  and John G. Baust

Part VI
Post-treatment Follow-up and Future Directions

Chapter 27
Setting Rules for Postablation and Follow-up
David S. Finley and Arie S. Belldegrun

Chapter 28
Roadmap for Focal Therapy
Thomas J. Polascik and Vladimir Mouraviev