Main description:

This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Contents:

Chapter 1_Importance of animal models in the field of cancer research. -Chapter 2_Cancer study: cell to the animal models. -Chapter 3_Animal models for cancer research: the choice of the right model system. -Chapter 4_Mouse as a model for different types of cancer. -Chapter 5_Zebrafish as an animal model for cancer research. -Chapter 6_Animal models for angiogenesis on cancer research. -Chapter 7_Orthotopic PDX and CDX mice model for cancer stem cell research. -Chapter 8_Chemical-induced hepatocellular carcinoma in Animal Model. -Chapter 9_Animal model of Breast Cancer. -Chapter 10_The use of mouse to model human colorectal cancer. -Chapter 11_Translatability of experimental animal cancer models for clinical development of biomarkers. -Chapter 2_Available preclinical tools for Neuroblastoma. -Chapter 13_Animal model of human cancer: Malignant lymphoma/ Colon Cancer/ lung Cancer/ Liver Cancer/ Brain Tumors/Skin cancer. -Chapter 14_Tumor models of Retinoblastoma: in vivo, ex vivo and in vitro models. -Chapter 15_Animal models for bone metastasis study. -Chapter 16_Animal model of Inflammatory Bowel Disease leading to cancer and Role of Genetic variation in colitis associated cancer. -Chapter 17_Animal Models in Women Cancer Research. -Chapter 18_Chorioallantoic membrane (CAM) and in ova models as potential platforms for testing cancer agents. -Chapter 19_Triple-negative breast cancer (tnbc) - clinical features and therapeutic targets. -Chapter 20_Role of Melatonin in Zebrafish Cancer Model. -Chapter 21_Stem Cell-derived Exosomes a promising therapeutic role in colorectal cancer. -Chapter 22_Optical Techniques for Treatment and Tissue Evaluation using Skin models for pre-clinical studies. -Chapter 23_Endocrine Regulation of Cancer in Zebra Fish Model. -Chapter 24_A study on the role of phytochemicals in the preclinical neuronal cancer. -Chapter 25_Prespectives of stem cell therapy: A promising therapeutic for cancer model and Alzheimers disease. -Chapter 26_Engineering exosomes for cancer theranostic applications using animal model. -Chapter 27_Use of Stem Cells on Animal Model of Cancer Research. -Chapter 28_Limitation and Advantages of MicroRNA Research in Colorectal Cancer Animal Model. -Chapter 29_Role of Telomere and Telomerase Activator (TA-65) in ageing and cancer. -Chapter 30_Analyzing the therapeutic efficacy and toxicity of chemicals and biological using animal models. -Chapter 31_Understanding the crosstalk between the experimental animal model and RNA interference: as a novel approach for cancer research. -Chapter 32_Genetics of Pancreatic Carcinogenesis: Current Molecular Insights from Animal Models. -Chapter 33_Genetically engineered and spontaneous animal model: utilization in preclinical cancer therapy development. -Chapter 34_Engineering and studying syngeneic animal tumors and Large animal endogenous tumor models. -Chapter 35_Role of animal research to understand the prospects for chemoprevention of cancer. -Chapter 36_Therapeutic molecular targets of cancer and animal models: adequacy and drawbacks. -Chapter 37_Terpenoids as chemopreventive agents and their interpretation in animal models and human clinical trials. -Chapter 38_Dectection of tumors through fluroscein conjugated dye in animal model. -Chapter 39_Biomaterials based drug delivery for cancer treatment: Use of Animal Models. -Chapter 40_Radiopharmaceuticals - A New Era in Cancer Therapy: Light on initial findings on Animal Model. -Chapter 41_Cancer modeling: modern imaging applications in the development of a unique animal model system to analyze cancer advancement and treatment. -Chapter 42_Experimental model for pancreatic cancer and its therapeutic implications in clinical research. -Chapter 43_Association of animal models in the field of cancer translational medicine: Prediction and Validation. -Chapter 44_Bioreactor Based Tissue Models as an Alternative Approach in Cancer Research. -Chapter 45_Repurposing of Drug in cancer research: Utility of Animal Models. -Chapter 46_Precilinical Data translation into clinical model. -Chapter 46_Alternative animal models in cancer research.