This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.
Section 1 The Genome Tools and Methods 1. The Newly Emerging View of the Genome Stephan Sanders 2. Genetic Epidmeiology Kathleen Ries Merikangas 3. Common Variation Mark Daly 4. Rare/Structural Variation Daniel Barrera and Jonathan Sebat 5. Epigenetics and Epigenomics Eric J. Nestler and John Greally 6. Bioinformatics Shaun Purcell 7. Imaging Genomics Paul Matthew Thompson 8. Stem Cell Technology and Genomics Alysson Renato Muotri 9. Association Strategies Benjamin M. Neale 10. The promise of Systems Biology Eric Schadt 11. Gene networks in neuropsychiatric disease Daniel Geschwind 12. Mosaicism Christopher A. Walsh and Saumya Shekhar Jamuar Section 2 A new neuroanatomy 13. Mapping the Molecular Landscape of the Human Brain Nenad Sestan 14. Studying Circuits Stephan Lammel and Robert Malenka 15. Electrophysiological Measurement of Circuits Srikantan S. Nagarajan 16. Imaging the Circuitry of the Human Brain Michael Greicius 17. Neuroimaging Advances in Alzheimer's Disease Daniel R. Schonhaut and Gil Rabinovici 18. Progressive Supranuclear Palsy and Related Parkinsonian Disorders Jesse A. Brown and William Seeley 19. The Anatomy of Basal Ganglia Circuitry of Behavior Nicholas Au Yong, Adrienne M. Keener, Yvette Bordelon, Carlos Portera-Cailliau and Nader Pouratian 20. Brainstem Circuitry of Behavior Helmut Heisen 21. Apathy - Basal Ganglia, Frontal Circuits Mario F. Mendez 22. Emotion Circuitry Robert Wayne Levenson 23. Delusions Georges Naasan 24. Hallucinations Dennis Velakoulis Section 3 Clinical Phenomenology 25. Intro: Risk Overlap Among Disorders Patrick Sullivan 26. The conundrum of Clinical Characterization RDOC/ICD-10/DSM Bruce N. Cuthbert 27. Schizophrenia Aiden Corvin 28. Psychosis Raquel E. Gur and Ruben Gur 29. ASD Rebecca Ann Muhle, Stephan Sanders, Hannah Reed and Matthew William State 30. Bipolar Disorder Nelson B. Freimer, Carrie E. Bearden and Peter Zandi 31. MDD David C. Glahn 32. Speech and Language Disorders Marilu Gorno-Tempini 33. Molecular Pathways Leading to the Clinical Phenomenology of Frontotemporal Dementia Suzee Eurie Lee and Jennifer S. Yokoyama 34. Alzheimer's Rudy Tanzi 35. PTSD Kerry Ressler 36. Neurodevelopmental syndromes Elliott Sherr 37. Epilepsies Ryan S. Dhindsa, Daniel Lowenstein and David Goldstein 38. Substance Abuse Nii Addy 39. Neuroimmunology Emmanuel Mignot 40. Brain Tumors Vanessa Clark and Murat Gunel 41. White Matter Disorders Michael David Geschwind and Brianne Magouirk Bettcher 42. ALS Elena Ratti and James Berry 43. Eating Disorders Cynthia M. Bulik and Garret Stuber Section 4 Clinical Translation and Drug Development 44. Pharmacogenomics Roy H. Perlis