Main description:

This volume reviews our current knowledge concerning can Several chapters discuss the contributions of genetic asp cer growth and progression as it relates to the etiology of ects, metabolism, endocrine-related aspects and nutrition to human cancer. As emphasized in Volumes I-V of this series, cancer progression. Moreover, our current knowledge con neoplastic diseases are multistep maladies. There are many cerning urbanization factors, radiation, therapy-induced causes for the appearance of neoplastic diseases. Earlier neoplasms, environmentally induced neoplasms (e. g. , chapters in the series have reviewed molecular and cellular mesotheliomas induced by asbestos) and malignant neo aspects of tumor initiation, promotion and progression to plasms in organ transplant recipients are summarized. the invasive and metastatic phenotype. Contributions to the The impact of AIDS on neoplasm development is re initiation and progression of neoplastic diseases are made by viewed from an epidemiologic perspective that explores mul natural features of the environment and by its contaminants tiple facets of immunity, infectious disease, sexual behavior and by nutritional factors. Neoplastic diseases show a dis and blood transfusion. Other chapters investigate the in tinct relationship to a variety of environmental stimuli and fluence of the host immune response in oncogenesis and the to diseases of a non-neoplastic nature. For example, familial relationship between atherosclerotic plaques and tumors.

Contents:

1. Neoplastic diseases - multistep maladies.- 2. Relationships between malignant and non-malignant diseases of Western culture.- 3. Genetic diseases, hamartomas, and familial occurrence of neoplasms.- 4. Genetic evaluation of ontologically related neural crest tumors.- 5. Multiple primary neoplasms: Comparison between Japan and the U.S.A..- 6. Selected aspects of primary liver carcinoma in Japan.- 7. Effects of localized and disseminated cancers on metabolism and nutrition in man.- 8. The natural untreated course of breast cancer.- 9. Hormone dependent breast cancer.- 10. Prolactin and estrogen in mammary tumorigenesis.- 11. Assessment of the endocrine risk of developing breast cancer.- 12. Appearance of neoplasms during pregnancy.- 13. Urbanization parameters as moderators of the background radiation-leukemia connection: Comparison with single variable and multifactor models.- 14. Radiation therapy-induced neoplasms.- 15. Chemotherapy-induced neoplasms, side effects and drug carcinogenicity.- 16. Malignant neoplasms in organ transplant recipients.- 17. Neoplastic progression induced by asbestos (mesothelioma).- 18. The concept of the immune reaction in oncogenesis: A host-tumor interaction.- 19. AIDS epidemic and neoplasms.- 20. The atherosclerotic plaque: Tumor or scar?.- 21. Neoplasms induced by non-cancer therapies.- 22. Secondary primary cancers: An overview.- 23. Observations of primary and secondary lesions in the same patient.- 24. Computer simulation of heterogeneity of tumor behavior.- Index of subjects.