Main description:

Having been a fairly dormant specialty for many decades, in recent years there has been a remarkable increase in activity in Neuro-oncology from basic science through to the clinics. Reflecting this there have been considerable advancements in the understanding of the biology of CNS malignancies which have infirmed the development of many novel and successful therapies. This work aims to bring together the scattered literature on the new concepts in neuro-oncology for the benefit of those in the field. The book moves from concepts in the scientific basis of neuro-oncology, through to modelling techniques and finishing on the translation into clinical practice.

Feature:

The main feature of this book is that it consolidates and elucidates information that is currently scattered

With a focus on translational research, this book is perfectly suited to a field such as neuro-oncology where the scientific basis is undergoing dramatic advances

Each chapter author, a leader in their subspecialty, has been carefully selected by the editor so that the reader is offered material of the highest calibre

Back cover:

Neuro-oncology is one of the most exciting and rapidly evolving areas of oncology. In recent years there has been a remarkable increase in activity in the field, from basic science through to the clinic. This is reflected by advances in the understanding of the biology of CNS malignancies which have informed the development of novel and successful therapies.  In this environment it is essential to facilitate communication and understanding of new ideas and concepts.

Emerging Concepts in Neuro-Oncology is written with this in mind: to encourage collaboration across traditional boundaries and promote translational research for patient benefit. The book moves from concepts in the scientific basis of neuro-oncology in part one, through models of brain cancer in part two, to emerging concepts in clinical practice in part three, with a focus on translational research.

This book will be an essential read for neuroscience researchers, cancer researchers, neurosurgeons and clinical oncologists as well as anyone with an interest in this exciting, dynamic field.

Contents:

Part I    Scientific Foundations

1.       Classification of Gliomas

                Pieter Wesseling

2.       Epigenetics and Brain Cancer

                Davide Sciuscio and Monika E. Hegi

3.       Astrocyte Differentiation from Oligodendrocyte Precursors

                Akiko Nishiyama

4.       Stem Cells and Brain Cancer

                Sara G.M. Piccirillo

Part II        Models of Brain Cancer

5.       In Vitro Models of Brain Cancer

                David J. Ryan and Colin Watts

6.       Mouse Models of Glioma Pathogenesis: History and State of the Art

                Sebastian Brandner

7.       The Application of Novel Ionising Radiation Species for Glioblastoma

                Raj Jena

8.       Advances in Imaging Brain Cancer

                Stephen J. Price and Adam D. Waldman

Part III    Emerging Concepts in Clinical Practice

9.       Surgical Management of Glial Cancers

                Walter Stummer

10.   Radiation Oncology in Brain Cancer

                Susan C. Short

11.   Managing the Elderly Patient

                Anthony J. Chalmers and Kathryn Graham

12.   Brain Tumour Presentation in Children and Young People

                David A. Walker and Sophie Wilne

13.   How Can We Improve Clinical Trial Recruitment in Neuro-Oncology?

                Sarah Jefferies