Main description:

Having been a fairly dormant specialty for many decades, in recent years there has been a remarkable increase in activity in Neuro-oncology from basic science through to the clinics. Reflecting this there have been considerable advancements in the understanding of the biology of CNS malignancies which have infirmed the development of many novel and successful therapies. This work aims to bring together the scattered literature on the new concepts in neuro-oncology for the benefit of those in the field. The book moves from concepts in the scientific basis of neuro-oncology, through to modelling techniques and finishing on the translation into clinical practice.

Contents:

Part I Scientific Foundations

1. Classification of Gliomas

Pieter Wesseling

2. Epigenetics and Brain Cancer

Davide Sciuscio and Monika E. Hegi

3. Astrocyte Differentiation from Oligodendrocyte Precursors

Akiko Nishiyama

4. Stem Cells and Brain Cancer

Sara G.M. Piccirillo

Part II Models of Brain Cancer

5. In Vitro Models of Brain Cancer

David J. Ryan and Colin Watts

6. Mouse Models of Glioma Pathogenesis: History and State of the Art

Sebastian Brandner

7. The Application of Novel Ionising Radiation Species for Glioblastoma

Raj Jena

8. Advances in Imaging Brain Cancer

Stephen J. Price and Adam D. Waldman

Part III Emerging Concepts in Clinical Practice

9. Surgical Management of Glial Cancers

Walter Stummer

10. Radiation Oncology in Brain Cancer

Susan C. Short

11. Managing the Elderly Patient

Anthony J. Chalmers and Kathryn Graham

12. Brain Tumour Presentation in Children and Young People

David A. Walker and Sophie Wilne

13. How Can We Improve Clinical Trial Recruitment in Neuro-Oncology?

Sarah Jefferies