Main description:

First published in 1992. Dermal Immune System discusses the structural and functional characterizations of the dermal immune system, including dermal dendritic cells, monocyte/macrophages, microvascular endothelial cells, pericytes, veil cells, fibroblasts, mast cells, dermal T lymphocytes, and peripheral nerve endings. This information is invaluable for gaining an understanding of how multicellular complex networks interface within the dermis and between the exogenous environment and endogenous milieu. Specific examples are provided that document the involvement of the dermal immune system in the pathophysiology of several skin diseases that result from perturbation of normal cutaneous homeostasis.

Dermal Immune System is an excellent reference volume that should always be close at hand for immunologists, cell biologists, investigative dermatologists, pathologists, and clinicians involved in the care of patients with skin disease.

Contents:

Dermal Immune System: The Immunobiology of Dermis (B.J. Nickoloff). The Dermal Dendrocytes (J.T. Headington). Dermal Cells: Underappreciated Components of Skin Associated Lymphoid Tissues (SALT) (J.W. Streilein). Human Blood Dendritic Cells (P.S. Freudenthal and G.S. Wood). Phenotypic Heterogeneity of the Dermal Monocyte/Macrophage System (W. Sterry & W.H. Boehncke).The Dermal Microvascular Unit: Relationship to Immunological Processes and Dermal Dendrocytes (J.M. Braverman). Immunological Repertoire of the Dermal Microvascular Unit (R. Sontheimer and M.D. Tharp). Phenotypic Diversity and Biologic Potential of Microvascular Endothelial Cells in-vivo and in-vitro (M.A. Karasek). Dermal Fibroblast Function (A. Postlethwaite). Interaction of Immune and Connective Tissue Cells (J. Korn and T. Piela-Smith). Inhibition of Dermal Fibrosis by Interferons (B. Berman and M.R. Duncan). The Secret of "NIN": A Novel Neural-Immunological Network Potentially Integral to Immunologic Function in Human Skin (G.F. Murphy). Heterogeneity Among CD36+ Cells in Normal and Diseased Human Skin (C.A. Foster). Dermal Dendrocytes: Key Players in the Pathogenesis of Benign and Malignant Lymphocytic Mediated Skin Disease (D.F. Fivenson). Heterogeneity of Macrophages in Skin Granulomas (W.L. Epstein). The Local Immune Response in Leprosy (J. Bertolli and R.L. Modlin).