Main description:

This book provides a practically applicable guide to the management of liver metastases in cases of colorectal cancer. It features detailed reviews of the latest diagnostic and therapeutic options. Instruction on how to appropriately apply surgical techniques including two stage hepatectomy as well as both laprascopic and open resection in a variety of scenarios is covered. The use of systemic therapies involving oxaliplatin, immunotherapy and infusional therapy are also described along with a range of surveillance strategies.

Vauthey and Adam Colorectal Liver Metastasis comprehensively covers the latest advances in how to successfully diagnose and treat colorectal liver metastases and is an indispensable resource for all trainee and practicing medical professionals who encounter these patients within their clinical practice.

Contents:

1 History of treatment of colorectal liver metastases 2 Anatomy 3 Exposure 4 Anatomic versus non-anatomic resection 5 Simulation and navigation 6 Advanced techniques in multiple metastases: fiduciary markers and completion ablation 7 Two-stage hepatectomy for biloblar colorectal liver metastases: experience of MD Anderson Cancer Center 8 Two-stage hepatectomy for biloblar colorectal liver metastases: experience of Hopital Paul-Brousse 9 One-stage hepatectomy for biloblar colorectal liver metastases: experience of the University of Tokyo 10 Associated Liver Partition and Portal vein ligation for Staged hepatectomy (ALLPS) 11 Open resection technique 12 Laparoscopic resection technique: Norwegian experience 13 Laparoscopic resection technique: French experience 14 Laparoscopic resection technique: Japanese experience 15 Is there a place for robotic resection? 16 Advanced resection technique with vascular reconstruction 17 Resection margins 18 R1 vascular resection 19 Prevention and treatment of perihepatic fluid collection including two-step air leak test 20 Synchronous presentation of primary and colorectal liver metastasis: classic, reverse, and combined 21 Approach to synchronous lung and liver metastases and single incision combined resection 22 Perioperative chemotherapy: review of randomized trials and recommended approach 23 The disappearing metastasis 24 Downsizing of unresectable colorectal liver metastasis 25 Is there a place for debulking? 26 Liver transplantation 27 Prognostic model for colorectal liver metastasis 28 Personalized prognostic model (contour model) 29 Conditional recurrence-free survival 30 Repeat Hepatectomy: Rationale and Results 31 Initial systemic chemotherapy for metastatic CRC 32 Treatment refractory metastatic CRC 33 Targeted therapy beyond EGFR and VEGF 34 Adjuvant systemic chemotherapy 35 Immunotherapy 36 Infusional therapy: European experience 37 Infusional therapy: American experience 38 Optimal diagnostic imaging of CLM in surgical candidates 39 Prevention of postoperative liver insufficiency including standardized future liver remnant and kinetic growth rate 40 Portal vein embolization with and without hepatic vein occlusion 41 Radiofrequency ablation, electroporation and microwave ablation 42 Radiation therapy 43 Radioembolization 44 Hepatic injury from chemotherapy 45 Imaging response criteria 46 Pathological response criteria 47 Histopathological patterns of progression and vessel co-option 48 Micrometastasis 49 Liquid biopsy 50 Multigene testing for prognostication and therapeutic actionability 51 Cancer-related signaling pathway and prognosis 52 Intra-operative ultrasound 53 Hybrid room for combined procedures 54 Liver tumor board 55 Role of advanced practice providers in enhancing perioperative and intraoperative patient care 56 Enhanced recovery after liver resection 57 Improved survival after CLM resection over 20 years 58 LiverMetSurvey registry 59 Surveillance strategy and circulating DNA