Main description:

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis.This book is the third of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Contents:

Role of chemokines in colorectal cancer
Extracellular vesicles in colorectal cancer growth, metastasis, diagnosis and therapy
Epigenetic regulation of colorectal cancer (CRC): Mechanism and Therapeutic Interventions
Mechanistic exploration and therapeutic management of colon cancer metastasis.
Chemoresistance in colon malignancies: Molecular mechanism and strategies to overcome
Targeting pathogenic inflammation for therapeutic intervention against colon cancer
Role of tumor associated macrophages in colon cancer progression and its therapeutic targeting
Therapeutic intervention of signaling pathways in colorectal cancer
Advances in chemoradiotherapy for treatment of colon cancer
Cytotoxic and chemopreventive activity of polyphenols and their derivatives in colon cancer
Prevention and management of colon cancer by nutritional intervention
Development of RNA based medicine for colorectal cancer: current scenario
Role of food additives and intestinal microflora in colorectal cancer
Probiotics in colon cancer: a therapeutic approach
Bacterial cancer therapy: promising role in the treatment of colon cancer
Antineoplastic effects of curcumin against colorectal cancer: application and mechanisms
Cyanobacterial secondary metabolite: A potential drug candidates against colon cancer
Clinical Significance of Genetic Variants in Colon Cancer