Main description:

Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing.

The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations.

Contents:

1. Introduction 2. Physiologic Changes During Pregnancy 3. Impact of Pregnancy on Maternal Pharmacokinetics of Medications 4. Medications and the Breastfeeding Mother 5. Fetal Drug Therapy 6. Treating the Placenta: An Evolving Therapeutic Concept 7. What is Sufficient Evidence to Justify a Multicenter Phase 3 Randomized Controlled Trial in Obstetrics? 8. Ethics of Clinical Pharmacology Research in Pregnancy 9. Pharmacogenomics in Pregnancy 10. Analgesics and Anti-Inflammatory, General and Local Anesthetics and Muscle Relaxants 11. The Management of Asthma During Pregnancy 12. Updated Guidelines for the Management of Nausea and Vomiting of Pregnancy 13. Clinical Pharmacology of Anti-Infectives During Pregnancy 14. Chemotherapy in Pregnancy 15. Substance Use Disorders 16. Diabetes in Pregnancy 17. Cardiovascular Medications in Pregnancy 18. Antidepressants in Pregnancy 19. Uterine Contraction Agents and Tocolytics 20. Antenatal Thyroid Disease and Pharmacotherapy in Pregnancy 21. Dermatological Medications and Local Therapeutics 22. Vitamins, Minerals, Trace Elements, and Dietary Supplements 23. Herbs and Alternative Remedies 24. Envenomations and Antivenoms During Pregnancy 25. Gastrointestinal Disorders