Main description:

In the years following publication of the DSM-5 (R), the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this
reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis.

In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text.

In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer
groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit.

Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as
a reflection of research progress.

The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5 (R), which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in
heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Contents:

Section 1: Emerging and Established Technologies
1. Genetic Methodologies and Applications
Shaun M. Purcell
2. Network Methods for Elucidating the Complexity of Common Human Diseases
Eric E. Schadt
3. The Human Brain and its Epigenome
Andrew Chess and Schahram Akbarian
4. Methods for In Vivo Gene Manipulation
Lisa M. Monteggia and Wei Xu
5. Application of Stem Cells to Understanding Psychiatric Disorders
Zijia Zhang and Kristen Brennand
6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges
Lief E. Fenno and Karl Deisseroth
7. In Vivo Circuit Analysis
Ryan Bowman, Hannah Schwennsen, Kafui Dzirasa, and Rainbo Hultman
8. Magnetic Resonance Methodologies
Peter A. Bandettini and Hanzhang Lu
9. PET Brain Imaging Methodologies
Ansel T. Hillmer, Kelly P. Cosgrove, and Richard E. Carson
10. Neuromodulation and Psychiatric Disorders
Wayne K. Goodman and Mark S. George
11. The Neurobiology of Sleep
Giulio Tononi and Chiara Cirelli

Section 2: Psychotic Disorders
12. Diagnosis and Epidemiology of Psychotic Disorders
Emma Meyer, Julie Walsh-Messinger, and Dolores Malaspina
13. Genetics of Schizophrenia and Bipolar Disorder
Pamela Sklar
14. Neuroimaging of Psychotic Disorders
Stephan Heckers, Neil Woodward, and Dost OEngur
15. Animal and Cellular Models of Psychotic Disorders
Mikhail V. Pletnikov, Guo-Li Ming, and Christopher A. Ross
16. Cognitive and Motivational Neuroscience of Psychotic Disorders: Animal and Human Studies
Jared Young, Alan Anticevic, and Deanna M. Barch
17. Synaptic Mechanisms of Psychotic Disorders: Animal and Human Studies
Seth G. N. Grant
18. Cellular Mechanisms of Psychotic Disorders: Human Studies
Samuel J. Dienel and David A. Lewis
19. Neurodevelopmental Mechanisms for Psychotic Disorders: Animal and Human Studies
Nao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, and Akira Sawa
20. The Neurobiology and Treatment of Bipolar Disorder
Katherine E. Burdick, Luz H. Ospina, Stephen J. Haggarty, and Roy H. Perlis
21. Novel Approaches for Treating Psychotic Disorders
Tiago Reis Marques and Shitij Kapur
22. Current Treatments for Psychotic Disorders
Deepak K. Sarpal and Anil K. Malhotra

Section 3: Depression
23. Diagnosis and Epidemiology of Depression
Nicholas T. Van Dam, Brian M. Iacoviello, and James W. Murrough
24. Genetics of Depression
Douglas F. Levinson and Walter E. Nichols
25. Neuroimaging of Depression
Michele A. Bertocci and Mary L. Phillips
26. Animal Models of Mood Disorders
Lyonna F. Alcantara, Eric M. Parise, and Carlos A. Bolanos-Guzman
27. Neurotrophic Mechanisms of Depression: Animal and Human Studies
Ronald S. Duman
28. Immune Mechanisms of Depression
Caroline Menard, Madeline L. Pfau, Georgia E. Hodes, and Scott J. Russo
29. Neuroendocrine Mechanisms of Depression: Clinical and Preclinical Evidence
Jill M. Goldstein, L Holsen, S Cherkerzian, M Misra, and RJ Handra
30. New Approaches for Treating Depression
Eric J. Nestler
31. Current Treatments for Depression
John H. Krystal and Dennis S. Charney

Section 4: Anxiety Disorders
32. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive and Trauma- and Stressor-Related Disorders
Murray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne
33. Genetics of Anxiety Disorders
Takeshi Otowa, Roxann Roberson-Nay, Mandy Bekhbat, Gretchen N. Neigh, and John M. Hettema
34. Functional Neurocircuitry and Neuroimaging Studies of Anxiety Disorders
Madeleine S. Goodkind and Amit Etkin
35. Animal Models and Assays Probing anxiety Related Behaviors and Neural Circuits
Ramon Tasan and Nicholas Singewald
36. Distinct Neural Mechanisms Underlying Fear and Anxiety
Joseph LeDoux
37. Synaptic and Circuit Mechanisms of Anxiety Disorders: Animal and Human Studies
Anfei Li, Francis S. Lee
38. The Neurobiology of Resilience
Adriana Feder, Sarah R. Horn, Margaret Haglund, Steven M. Southwick, and Dennis S. Charney
39. Novel Approaches for Treating Anxiety Disorders
David A. Sturman,Milissa L. Kaufman, Cara E. Bigony, and Kerry J. Ressler
40. Novel treatment approaches for anxiety disorders
Adam J. Guastella, Alice Norton, Gail A. Alvares, and Christine Song

Section 5: Substance Use Disorders
41. Epidemiology of Substance Use Disorders
Denise B. Kandel, Mei-Chen Hu, Pamela C. Griesler, Bradley T. Kerridge, and Bridget F. Grant
42. The Genetic Basis of Addictive Disorders
David Goldman, Zhifeng Zhou, and Colin Hodgkinson
43. Animal Models of Addiction
Christopher Evans J., Brigitte L. Lieffer, David Jentsch, and Rafael J. Maldonado
44. Reward Circuitry and Drug Addiction
Vaughn R. Steele, Vani Pariyadath, Rita Z. Goldstein, and Elliot A. Stein
45. Molecular Neuroimaging in Addictive Disorders
Edythe D. London and Chelsea L. Robertson
46. Cellular and Molecular Mechanisms of Addiction
Kathryn J. Reissner and Peter W. Kalivas
47. Brain Development and the Risk for Substance Abuse
Mary M. Heitzeg and B.J. Casey
48. Pharmacotherapy of Substance Use Disorders
Jane B. Acri and Phil Skolnick
49. Current Approved Pharmacotherapies for Substance Use Disorders
Alexis S. Hammond and Eric C. Strain

Section 6: Dementia
50. Diagnosis and Epidemiology of Dementia
William C. Kreisl and Christiane Reitz
51. Genetics of Dementia
Alan E. Renton and Alison M. Goate
52. Neuroimaging and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease
Brian A. Gordon, Stephanie J.B. Vos, and Anne M. Fagan
53. Animal Models of Alzheimer's Disease
David Morgan
54. Cellular Mechanisms of Dementia: Animal and Human Studies
Li Gan
55. Neurobiology of Lewy Body Dementias: Animal and Human Studies
James E. Galvin and Jose Tomas Bras
56. Neurobiology of FTD: Animal and Human Studies
Dah-eun Chloe Chung, Jeannette N. Stankowski, and Leonard Petrucelli
57. Current Treatments for Alzheimer's Disease
Mary Sano and Judith Neugroschil

Section 7: Psychiatric Disorders of Childhood Onset
58. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders of Childhood
Elise Robinson, Benjamin Neale, and Mark Daly
59. Genetics of Pediatric Psychiatric Disorders
Silvia de Rubeis, M. Pilar Trelles, and Joseph D. Buxbaum
60. Neuroimaging in Pediatric Psychiatric Disorder
Timothy P.L. Roberts and Luke Bloy
61. Animal and Cellular Models of Pediatric Psychiatric Disorders
Elodie Drapeau, Hala Harony-Nicolas, and Jacqueline N. Crawley
62. Neurodevelopmental Mechanisms of Pediatric Psychiatric Disorders: Animal and Human Studies
Silvia De Rubeis, Kathryn Roeder, and Bernie Devlin
63. Neurobiology of Autism Spectrum Disorder and Intellectual Disability: Animal and Human Studies
Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick Hof, Joseph D. Buxbaum, and Alexander Kolezvon
64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies
Stephen V. Faraone, Pradeep G. Bhide, and Joseph Biederman
65. The Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Human and Animal Studies
Christopher Pittenger
66. Neurobiology of Eating Disorders: Animal and Human Studies
Thomas Hildebrandt and Ashley Heywood
67. Novel Approaches for Treating Pediatric Psychiatric Disorders
Supritha Prasad and Edwin H. Cook, Jr.
68. Current Treatments for Pediatric Psychiatric Disorders
M. Pilar Trelles, Paige Siper, and Dorothy Grice
Section 8: Future of Psychiatric Diagnosis: Toward Precision Psychiatry

69. DSM-5 (R) Overview and Goals
Darrel A. Regier, Sarah E. Morris, and Susan K. Schulz
70. The Present and Future of Psychiatric Diagnosis
Steven E. Hyman
71. The NIMN Research Domain Criteria Project: Toward Precision Medicine in Psychiatry
Bruce N. Cuthbert
72. Computational Psychiatry and the Bayesian Brain
Karl J. Friston and Raymond J. Dolan