Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed. Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice.
Section I. General Aspects 1. The use of cerebrospinal fluid in biomarker studies 2. The cerebrospinal fluid and barriers - anatomical and physiological considerations 3. More than a drainage fluid: the role of CSF in signalling in the brain and other effects on brain tissue 4. Dosing, collection and quality control issues in cerebrospinal fluid research using animal models Section II. CSF Research in Particular Disease Entities and its Clinical Context 5. Multiple sclerosis, and other demyelinating and autoimmune inflammatory diseases of the central nervous system 6. Cerebrospinal fluid in the dementias 7. Biomarkers in cerebrospinal fluid for synucleinopathies, tauopathies, and other neurodegenerative disorders 8. Cerebrospinal fluid in Creutzfeld-Jakob disease 9. Cerebrospinal fluid findings in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathies 10. Cerebrospinal fluid biomarkers of malignancies located in the central nervous system 11. Impaired cerebrospinal fluid pressure 12. Cerebrospinal fluid in acute and chronic infectious diseases 13. Vascular diseases and bleedings 14. Cerebrospinal fluid and brain extracellular fluid in severe brain trauma 15. Epilepsy 16. Primary headaches 17. Psychiatric syndromes other than dementia