Main description:

This volume of the series Rare Diseases of the Immune System presents detailed state of the art knowledge on the cellular primary immunodeficiencies; it includes extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the T cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel cellular PID genes and related clinical applications, mucosal T cells, and the various clinical phenotypes of cellular PIDs. Cellular Primary Immunodeficiencies will be of high value for immunologists, pediatricians, rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD, Master and PhD students.

Contents:

Primary Immunodeficiencies

Genetics of Cellular Immunodeficiencies
Phenocopies of Primary Immuno Deficiencies
Dysfunctional immune synapses in T cell immunodeficiencies
Mucosal immunity in primary immunodeficiencies
Combined Immuno Deficiencies
Congenital defects of phagocytes

Defects in intrinsic and innate immunity
Diseases of immune dysregulation
IPEX syndrome and IPEX-related disorders

Autoinflammatory disorders
Lung in Cellular Immunodeficiencies
Gut involvement in Cellular Immunodeficencies
Malignancies in Cellular Immunodeficencies
Autoimmunity in Cellular Immunodeficencies
Differential diagnostic in Cellular Immunodeficiencies
Management of Cellular Immunodeficiencies
Vaccines in Cellular Immunodeficiencies
Gene therapy in Cellular Immunodeficiencies