(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
Contents:
S.S. Farid: Established Bioprocesses for Producing Antibodies as a Basis for Future Planning.- K.F. Wlaschin, W.-S. Hu: Fedbatch Culture and Dynamic Nutrient Feeding.- K. Konstantinov, C. Goudar, M. Ng, R. Meneses, J. Thrift, S. Chuppa, C. Matanguihan, J. Michaels, D. Naveh: The 'Push-To-Low' Approach for Optimitzation of High-Density Perfusion Cultures of Animal Cells.- C. Goudar, R. Biener, C. Zhang, J. Michaels, J. Piret, K. Konstantinov: Towards Industrial Application of Quasi Real-Time Metabolic Flux Analysis for Mammalian Cell Culture.- G. Seth, P. Hossler, J.C. Yee, W.-S. Hu: Engineering Cells for Cell Culture Bioprocessing-Physiological Fundamentals.-
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: November, 2010
Pages: 182
Weight: 454g
Availability: Available
Subcategories: Biochemistry
From the same series
Harald Seitz
Jens Schrader
Jian-Jiang Zhong
M. Butler
Wolfgang Babel
Cornelia Kasper
Man Bock Gu
Andreas Vilcinskas
Regine Eibl
Andreas Vilcinskas
Reiner Claus
Isao Endo
Ajay Singh
H. Jung
T. Gu
T. Yoshida
E. Heinzle
J.D. Phillipson
M.-R. Kula
Pauline M Doran
Yong-Hyun Lee
A. Fiechter
A. Arnaud
A. Fiechter
G.T. Tsao
A. Fiechter
T.K. Ghose
SK Gupta
J.P. Barford
T.K. Ghose
A. Fiechter
Isao Endo
H. Schneider
Harald Seitz
Cornelia Kasper
Jian-Jiang Zhong
Cornelia Kasper
Isao Endo
Christoph Wittmann
Jian-Jiang Zhong
Govind Rao
Regine Eibl
Ulrich Martin
Takeshi Kobayashi
Sven-Olof Enfors
Jens Nielsen
Michael Hecker
Robert Faurie
Urs Von Stockar
Lisbeth Olsson
Roland Ulber
Harald Seitz
Fred Lisdat
Ulf Stahl
Kyongbum Lee
Takeshi Kobayashi
Ioannis V. Yannas
Harald Seitz
Cornelia Kasper
Cornelia Kasper
Isao Endo
Christoph Wittmann
Maik W. Jornitz
Ioannis V. Yannas
Jens Nielsen
David V. Schaffer
Jens Rietdorf
Regine Eibl
Govind Rao
Ulrich Martin
Jian-Jiang Zhong
Cornelia Kasper
Harald Seitz
Ulf Stahl
Fred Lisdat
Lisbeth Olsson
Roland Ulber
Harald Seitz
Kyongbum Lee
Kyongbum Lee
Wei-Shu Hu
Maik W. Jornitz