Main description:

In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications. Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.

Contents:

Introduction and Rationale.- Administrative and Regulatory considerations.- FACT & JACIE Inspections: How to address and avoid common citations.- Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection.- Mobilization Strategies for HPC (A) collections in Autologous.- Mobilization Strategies for HPC (A) collections in Allogeneic Donors.- HPC (A) and Lymphocyte Collection: Technical Devices (Optia, Amicus, others) and operating parameters.- Anticoagulation and Other Peri-procedural Considerations for Apheresis.- Hematopoietic Stem and Progenitor Cell Collection: Prediction algorithms.- Applications of Apheresis Devices in Processing Bone Marrow Grafts.- Therapeutic Plasma Exchange and Immuoadsorption: Indications and implementation.- Red cell exchange: When and Why?.- Extracorporeal Photopheresis in Hematopoietic Cell Transplantation.- Prevention and Management of Apheresis Complications.- Application of Apheresis in Pediatric Donors: Clinical and Technical Aspects.- Challenges and Optimization of Apheresis Procedures in Resource-limiting Environments.