Main description:

Antioxidants Effects in Health: The Bright and the Dark Side examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants' historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.

Contents:

Part 1. Introduction 1. Evolution of antioxidants over times 2. The oxidative stress: Causes, free radicals, targets, mechanisms, affected organs, effects, indicators 3. Food autooxidation

Part 2. Endogenous antioxidants 4. Alpha lipoic acid 5. Bilirubin 6. Catalase 7. Coenzyme Q 8. Ferritin 9. Glucose-6-phosphate-dehydrogenase 10. Glutathione peroxidise 11. Glutathione reductase 12. Gluthathione 13. Superoxide dismutase 14. Uric acid

Part 3. Synthetic antioxidants: bright and the dark side 15. Ascorbyl palmitate 16. Butylated hydroxyanisole (BHA) 17. Butylated hydroxytoluene (BHT) 18. Erythorbic acid (D-ascorbic acid) 19. Nordihydroguaiaretic acid (NDGA) 20. Octyl gallate (OG) 21. Propyl gallate (PG) 22. tert-butylhydroxyquinone (TBHQ)

Part 4. Natural occurring antioxidants: bright and the dark side 23. Amino acids 24. Carnosine 25. Carnosol 26. Carotenoids (xanthophylls and carotenes) 27. Citric acid 28. Coenzyme Q 29. Curcumin 30. Flavonoids 31. Lecithin 32. Lignans 33. Organosulfur compounds( allyl sulphide, indoles) 34. Phenolic acids 35. Phytic acid 36. Protein hydrolysates 37. Saponins 38. Selenium 39. Sterols 40. Stilbenes 41. Tartaric acid 42. Turmeric 43. Uric acid 44. Vanillin 45. Vitamin A (retinol) 46. Vitamin C 47. Vitamin E (tocopherols and tocotrienols) 48. Vitamin K 49. Zinc

Part 5. Antioxidants and diseases: Beneficial and detrimental effects 50. Antioxidants and cancer 51. Antioxidants and cardiovascular diseases 52. Antioxidants and cataracts/ age-related macular degeneration 53. Antioxidants and cognitive decline in elderly 54. Antioxidants and dentistry 55. Antioxidants and diabetes 56. Antioxidants and gastric lesions 57. Antioxidants and immune functions 58. Antioxidants and infertility 59. Antioxidants and liver diseases 60. Antioxidants and neurological disorders and psychiatric disorders 61. Antioxidants and respiratory diseases 62. Antioxidants and viral diseases

Part 6: Actual and future perspectives on antioxidants 63. Duality: antioxidants/prooxidants 64. Food and food supplements antioxidants: Targets in human antioxidant system and effects on the production of endogenous antioxidants 65. Concluding remarks and future perspectives