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Acute Promyelocytic Leukemia
A Clinical Guide
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Main description:

This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.

Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.


Contents:

1 History of APLLaurent Degos 2 Molecular Targets of Treatment in APLRamy Rahme, Cecile Esnault, Hugues de The
3 The Leukemic Stem CellThalia Vlachou, Giulia De Conti, Anna Giulia Sanarico, Pier Giuseppe Pelicci
4 The Molecular Genetics of APLLourdes Mendez, Ming Chen, Pier Paolo Pandolfi
5 APL CoagulopathyAnna Falanga, Laura Russo, Pau Montesinos
6 Early Death in APLSoeren Lehmann
7 Prognostic Factors in APLJavier de la Serna, Pau Montesinos, Miguel A. Sanz
8 First-line therapy for APL: Chemotherapy-based approach Aaron D. Goldberg, Martin S. Tallman
9 First-line Therapy: ATRA-ATO/Reduced Chemotherapy ApproachHarry Iland
10 Cure of APL without ChemotherapyMary-Elizabeth M. Percival, Elihu H. Estey
11 Minimal Residual Disease in APLLaura Cicconi, Eva Barragan
12 Treatment of refractory and relapsed APLEva Lengfelder
13 Hematopoietic Stem Cell Transplantation in APLJaime Sanz, Miguel A. Sanz
14 APL in ChildrenMatthew A. Kutny, Anna Maria Testi
15 Management of APL in the ElderlyRamy Rahme, Lionel Ades, Pierre Fenaux
16 Special Situations in APLMassimo Breccia, Gloria Iacoboni, Miguel A. Sanz
17 APL in Developing Countries: A Chemotherapy-Based ApproachLuisa Correa de Araujo Koury, Raul Ribeiro, Eduardo M. Rego
18 APL in Developing Countries: ATO based ApproachVikram Mathews
19 Therapy-Related APLKristen Pettit, Richard A. Larson
20 Rare Acute Leukemia Variants involving Retinoic Acid Receptor GenesLaura Cicconi, Oussama Abla
21 Management of Treatment-Related Complications in APLOmbretta Annibali, Giuseppe Avvisati


PRODUCT DETAILS

ISBN-13: 9783319642567
Publisher: Springer (Springer International Publishing AG)
Publication date: May, 2018
Pages: 500
Weight: 6867g
Availability: Available
Subcategories: Haematology, Oncology

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