Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Abeloff's Clinical Oncology Sixth Edition PART I: SCIENCE AND CLINCIAL ONCOLOGY SECTION A: BIOLOGY AND CANCER 1. Molecular Tools in Cancer Research 2. Intracellular Signaling 3. The Cellular Microenvironment and Metastases 4. Control of the Cell Cycle 5. The Pathophysiology of Cancer Cell Death 6. Cancer Immunology 7. Stem Cells, Cell Differentiation, and Cancer 8. Vascular and Interstitial Biology of Tumors 9. Cancer Metabolism SECTION B: GENESIS OF CANCER 10. Environmental Factors 11. DNA Damage Response Pathways and Cancer 12. Viruses and Human Cancer 13. Genetic Factors: Hereditary Cancer Predisposition Syndromes 14. Genetic and Epigenetic Changes in Cancer SECTION C: DIAGNOSIS OF CANCER 15. Pathology, Biomarkers, and Molecular Diagnostics 16. Imaging SECTION D: CLINICAL TRIALS 17. Biostatistics and Bioinformatics in Clinical Trials 18. Trial Design 19. Structures Supporting Cancer Clinical Trials 20. Oncology and Health Care Policy SECTION E: PREVENTION AND EARLY DETECTION 21. Discovery and Characterization of Cancer Genetic Susceptibility Alleles 22. Lifestyle and Cancer Prevention 23. Cancer Screening and Early Detection 24. Nicotine Dependence: Current Treatments and Future Directions SECTION F: TREATMENT 25. Cancer Pharmacology 26. Therapeutic Targeting of Cancer Cells: Era of Molecularly Targeted Agents 27. Basics of Radiation Therapy 28. Hematopoietic Stem Cell Transplantation 29. Gene Therapy in Oncology 30. Therapeutic Antibodies and Immunologic Conjugates 31. Complementary and Alternative Medicine PART II: PROBLEMS COMMON TO CANCER AND THERAPY SECTION A: HEMATOLOGIC PROBLEMS AND INFACTIONS 32. Disorders of Blood Cell Production in Clinical Oncology 33. Diagnosis, Treatment, and Prevention of Cancer-Related Venous Thrombosis 34. Infection in the Patient with Cancer SECTION B: SYMPTOM MANAGEMENT 35. Hypercalcemia 36. Tumor Lysis Syndrome 37. Cancer-Related Pain 38. Cancer Cachexia 39. Nausea and Vomiting SECTION C: TREATMENT COMPLICATIONS 40. Oral Complications 41. Dermatologic Toxicities of Anticancer Therapy 42. Cardiovascular Effects of Cancer Therapy 43. Reproductive Complications 44. Paraneoplastic Neurologic Syndromes 45. Neurologic complications 46. Endocrine Complications 47. Pulmonary Complications of Anticancer Treatment SECTION D: POST TREATMENT CONSIDERATIONS 48. Rehabilitation of Individuals with Cancer 49. Survivorship 50. Second Malignant Neoplasms 51. Caring for Patients at the End of Life SECTION E: LOCAL EFFECTS OF CANCER AND ITS METASTASIS 52. Acute Abdomen, Bowel Obstruction, and Fistula 53. Superior Vena Cava Syndrome 54. Spinal Cord Compression 55. Brain Metastases and Neoplastic Meningitis 56. Bone Metastases 57. Lung Metastases 58. Liver Metastases 59. Malignancy-Related Effusions SECTION F: SPECIAL POPULATIONS 60. Cancer in the Elderly: Biology, Prevention, and Treatment 61. Special Issues in Pregnancy 62. Human Immunodeficiency Virus (HIV) Infection and Cancer PART III: SPECIFIC MALIGNANCIES SECTION A 63. Cancer of the Central Nervous System SECTION B 64. Ocular Tumors 65. Cancer of the Head and Neck SECTION C: SKIN 66. Melanoma 67. Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas SECTION D: ENDOCRINE 68. Cancer of the Endocrine System SECTION E: THORACIC 69. Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer 70. Diseases of the Pleura and Mediastinum 71. Cancer of the Esophagus and Gastroesophageal Junction SECTION F: GASTROINTESTINAL 72. Cancer of the Stomach and Gastroesophageal Junction 73. Cancer of the Small Bowel 74. Colon Cancer 75. Cancer of the Rectum 76. Cancer of the Anal Canal 77. Liver and Bile Duct Cancer 78. Carcinoma of the Pancreas SECTION G: GENITOURINARY 79. Cancer of the Kidney 80. Carcinoma of the Bladder 81. Prostate Cancer 82. Cancer of the Penis 83. Testicular Cancer SECTION H: GYNECOLOGICAL 84. Cancers of the Cervix, Vulva, and Vagina 85. Cancer of the Endometrium 86. Ovaries and Fallopian Tubes 87. Gestational Trophoblastic Disease 88. Cancer of the Breast SECTION I: SARCOMAS 89. Sarcomas of Bone 90. Sarcomas of Soft Tissue SECTION J 91. Carcinoma of Unknown Primary SECTION K: PEDIATRICS 92. Pediatric Solid Tumors 93. Childhood Leukemia 94. Childhood Lymphoma SECTION L: HEMATOLOGICAL 95. Acute Leukemias in Adults 96. Myelodysplastic Syndromes 97. Myeloproliferative Disorders 98. Chronic Myeloid Leukemia 99. Chronic Lymphoid Leukemias 100. Hairy Cell Leukemia 101. Multiple Myeloma and Related Disorders 102. Hodgkin's Lymphoma 103. Non-Hodgkin Lymphoma 104. Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma 105. Adult T-Cell Leukemia-Lymphoma