Main description:

This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.

Contents:

Introduction

1. Basic and Clinical Aspects of photodynamic Therapy
Valentina Rapozzi and Giulio Jori

Mechanistic Aspects Involved in Resistance to PDT

2. Mechanisms of Resistance to Photodynamic Therapy
Adriana G. Casas, Christian Perotti, Gabriela Di Venosa and Alicira Batlle

3. Tumor Vascular Microenvironment Determines responsiveness to Photodynamic Therapy
Shannon M. Gallagher-Colombo, Jarod C. Finlay and Theresa M. Busch

4. Autophagy Pathways Activated in Response to PDT Contribute to Cell Resistance Against ROS Damage
Abhishek D. Garg and Patrizia Agostinis

5. Methods to isolate the Resistant Cells to Photodynamic Therapy
Alicia Zamarron, Sara E. Lucena, Nerea Salazar, Pedro Jaen, Salvador Gonzalez, Yolanda Gilaberte and Angeles Juarranz

Specific Strategies to Sensitize Tumor Cells to PDT

6. GRP78-Targeting Subtilase Cytotoxin Sensitizes Cancer Cells to Photodynamic Therapy
Malgorzata Firczuk, Magdalena Gabrysiak and Jakub Golab

7. Optimization of Photodynamic Therapy Response by Survivin Gene Knockdown in Human Metastatic Breast Cancer
Viviana A. Rivarola and Ingrid Sol Cogno

8. Cellular Targets and Molecular Responses Associated with Photodynamic Therapy
Marian Luna, Angela Ferrario, Natalie Rucker, Emma Balouzian, Sam Wong, Sophie Mansfield and Charles J. Gomer

Approaches to Reduce the Multi-Drug Resistance of Tumor Cells by PDT

9. The Use of Nanoparticle-Delivered Photosensitizers Can Overcome the Development of Resistance to PDT in Tumors
Magali Toussaint, Muriel Barberi-Heyob, Sophie Pinel and Celine Frochot

10. Mechanisms of tumor cells resistance to ALA/PDT
Zvi Malik, Abraham Nudelman and Benjamin Ehrenberg

11. Overcoming the Resistance of Meolanoma to Photodynamic Therapy
Sulbha K. Sharma, Ying-Ying Huang and Michael R.Hamblin