This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions.Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.
I. Background1. Precision Medicine of Lung Cancer: Introduction2. Lung Cancer Epidemiology and Demographics3. Genetic Susceptibility to Lung Cancer4. Lung Cancer Stem Cells5. The 2015 World Health Organization Classification of Lung Cancer: OverviewII. Testing Methods6. Preanalytic considerations7. Mutation testing of lung cancer biomarkers8. Translocation testing of lung cancer biomarkers9. Immunohistochemistry of lung cancer biomarkers10. Next Generation and Third Generation Sequencing of lung cancer biomarkersIII. Molecular Pathology of Specific Cell Types11. Mutations as Predictive Biomarkers for Adenocarcinoma12. Translocations as predictive Biomarkers for Adenocarcinoma13. Predictive Biomarkers for Squamous Cell Carcinoma14. Molecular Pathology of Small Cell Carcinoma15. Molecular Pathology of Uncommon Carcinomas16. Molecular Pathology of Lung Cancer Metastases17. Molecular Pathology of Precursor and Preinvasive LesionsIV. General and Emerging Fields in Molecular Pathology of Lung Cancer18. Prognostic biomarkers in lung cancer19. Biomarkers and Differing Therapy Modalities20. Immuno-oncology of Lung Cancer21. Liquid Biopsy.