Main description:

This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions.
Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.

Contents:

I. Background

1. Precision Medicine of Lung Cancer: Introduction
2. Lung Cancer Epidemiology and Demographics
3. Genetic Susceptibility to Lung Cancer
4. Lung Cancer Stem Cells
5. The 2015 World Health Organization Classification of Lung Cancer: Overview

II. Testing Methods

6. Preanalytic considerations
7. Mutation testing of lung cancer biomarkers
8. Translocation testing of lung cancer biomarkers
9. Immunohistochemistry of lung cancer biomarkers
10. Next Generation and Third Generation Sequencing of lung cancer biomarkers

III. Molecular Pathology of Specific Cell Types

11. Mutations as Predictive Biomarkers for Adenocarcinoma
12. Translocations as predictive Biomarkers for Adenocarcinoma
13. Predictive Biomarkers for Squamous Cell Carcinoma
14. Molecular Pathology of Small Cell Carcinoma
15. Molecular Pathology of Uncommon Carcinomas
16. Molecular Pathology of Lung Cancer Metastases
17. Molecular Pathology of Precursor and Preinvasive Lesions

IV. General and Emerging Fields in Molecular Pathology of Lung Cancer

18. Prognostic biomarkers in lung cancer
19. Biomarkers and Differing Therapy Modalities
20. Immuno-oncology of Lung Cancer
21. Liquid Biopsy.