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MORE ABOUT THIS BOOK
Main description:
In Hormone Therapy in Breast and Prostate Cancer, many of today's leading researchers and clinicians describe the principles underlying targeted hormonal treatments, assess the actions of new and established agents, and illustrate the new applications of hormonal chemoprevention for breast cancer. Topics range from preclinical and clinical antiestrogens to the inhibition of estrogen synthesis and the effects of androgen withdrawal. A wide variety of proven and new agents are discussed-antiestrogens, including aromatase inhibitors (anastrozole, letrozole, and others), SERMs (tamoxifen, raloxifene, and others), and such antiandrogenic strategies as goserelin and bicalutamide.
Contents:
An Introduction to the Regulation of Sex Steroids for the Treatment of Cancer
V. Craig Jordan and Barrington J. A. Furr
Part I. Preclinical Antiestrogens
Antiestrogens and the Cell Cycle
Colin K. W. Watts, Owen W. J. Prall, Jason S. Carroll, Nicholas R. C. Wilcken, Eileen M. Rogan, Elizabeth A. Musgrove, and Robert L. Sutherland
Drug Resistance to Antiestrogens
Ruth M. O'Regan, Anait S. Levenson, Gale M. England, Kathy A. Yao, Henry D. Muenzner, Hiroyuki Takei, and V. Craig Jordan
Mechanisms of Liver Carcinogenesis by Antiestrogens
David H. Phillips
The Effects of Triphenylethylene Antiestrogens on Parameters of Multistage Hepatocarcinogenesis in the Rat
Yvonne P. Dragan and Henry C. Pitot
Preclinical Studies of Raloxifene and Related Compounds
Robin Fuchs-Young. Pure Antiestrogens, Alan E. Wakeling
Part II. Antiestrogens: Clinical
Tamoxifen for the Treatment of Breast Cancer
V. Craig Jordan
Clinical Utility of New Antiestrogens
Ruth M. O'Regan and William J. Gradishar
Breast Cancer Prevention with Antiestrogens
Monica Morrow and V. Craig Jordan
Part III. Inhibition of Estrogen Synthesis
Aromatase Inhibitors
Paul E. Goss and Caroline C. Reid
Clinical Utility of Aromatase Inhibitors
K. Shenton, Mitchell Dowsett, and Michael Dukes
LH-RH Agonists for the Treatment of Breast Cancer: Development and Current Status
Roger W. Blamey
Part IV. Androgen and Androgen Withdrawal
Molecular Action of Androgens
Shutsung Liao, Junichi Fukuchi, and Yung-Hsi Kao
Steroidal Antiandrogens
Fritz H. Schroeder and Albert Radlmaier
Nonsteroidal Antiandrogens
Geert J. C. M. Kolvenbag and Barrington J. A. Furr
LH-RH Agonist Role in Prostate Cancer Management
Amir V. Kaisary
Part V. Perspective on Progress
Recent Progress in Breast Cancer Research
V. Craig Jordan and Barrington J. A. Furr
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: September, 2009
Pages: 434
Weight: 1350g
Availability: Available
Subcategories: Endocrinology, Oncology, Pharmacology, Physiology
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