Main description:

This book summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation. Particular attention is paid to the still underestimated adaptive cardiac responses during development, to adaptation to the frequently occurring pressure and volume overload as well as to cardiac changes, induced by enduring exercise and chronic hypoxia. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.

Contents:

Part A DEVELOPMENTAL ASPECTS OF CARDIAC ADAPTATION

1. Comparative Aspects of Cardiac Adaptation
Bohuslav Ostadal

2. Molecular Mechanisms in Cardiac Development
Patricia Roche, Michael P. Czubryt, Jeffrey T. Wigle

3. Prenatal Adaptation to Overload
Zivorad Pesevski, David Sedmera

4. Hypoxia and Mechanical Factors Drive Coronary Vascular Development
Robert J. Tomanek

5. Cardiac Metabolic Adaptation During Postnatal Development
Jerome Piquereau, Marta Novotna, Anne Garnier, Frederic. Joubert, Vladimir Veksler, Renee Ventura-Clapier

6. Ontogenetic Adaptation to Chronic Hypoxia
Bohuslav Ostadal, Ivana Ostadalova, Zuzana Charvatova, Frantisek Kolar

7. Heart and Arterial Aging
Paul D. Chantler, Edward G. Lakatta

Part B CARDIAC ADAPTATIONS TO OVERLOAD

8. Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy
Alison L. Muller, Naranjan S. Dhalla

9. Cardiac Adaptation to Volume Overload
Vojtech Melenovsky

10. Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females
Melissa R. Dent, Vijayan Elimban, Amrit Malik, Paramjit S. Tappia, Naranjan S. Dhalla

11. Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations
Feriel Azibani, Claude Delcayre, Jane-lise Samuel

12. Cardiopulmonary Adaptation to High Altitude
Jean-Paul Richalet

13. Cardiac Hypertrophy in Hypertension
Jaroslav Kunes, Ivana Vaneckova, Michaela Kadlecova, Michal Behuliak, Zdenka
Dobesova, Josef Zicha,

14. Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice
Dirk J. Duncker, Elza D. van Deel, Monique C. de Waard, Jolanda van der Velden

15. The Athlete's Heart
Aaron L. Baggish

Part C MOLECULAR AND CELLULAR ASPECTS OF CARDIAC ADAPTATIONS

16. Role of - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy
Adriana Adameova, Paramjit S. Tappia, Naranjan S. Dhalla

17. Role of Phospholipase C in the 1 - Adrenoceptor Mediated Cardiac Hypertrophy
Paramjit S. Tappia, Adriana Adameova, Naranjan S. Dhalla

18. Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart
Michael Wagner, M.A.Q. Siddiqui

19. Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy
Vinod B. Pillai, Mahesh P. Gupta

20. Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection
Enn Seppet, Ehte Orlova, Teet Seene, Frank N. Gellerich

21. Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor
Morris Karmazyn, Xiaohong Tracey Gan

22. Myocardial Adaptation and Autophagy
Dipak K. Das, Hannah R. Vasanthi

23. Modulatory Role of VEGF in Angiogenesis for Cell Survival
Dipti Gatne, Veeranjaneyulu Addepalli, Dev D. Santani

24. The Role of CaM Kinase II in Cardiac Function in Health and Disease
Adriana Adameova, Adrian Szobi, Slavka Carnicka, Tanya Ravingerova, Tomas Rajtik